Monteggia Lab



1.         Monteggia LM  (2011)  Towards Neurotrophin-based therapeutics.  Am J Psychiatry, 168(2):114-116.
2.         Na ES, Monteggia LM (2011) The Role of MeCP2 in CNS Development and Function.  Hormones and Behavior.  Horm Behav  59(3):364-368.
3.         Kavalali ET, Nelson ED, Monteggia LM  (2011)  Role of MeCP2, DNA methylation and HDACS in Regulating Synapse Function.  Journal of Neurodev Disord.
4.         Sara Y, Adachi M, Monteggia LM, Kavalali ET  (2011)  Spontaneous and evoked glutamate release activates distinct populations of AMPA receptors. Journal of Neurosci 31(14):5378-5382.
5.         Nelson ED, Monteggia LM (2011) Epigenetics in the Mature Mammalian Brain:  Effects on Behavior and Synaptic Transmission.  Neurobio Learn Mem  [Epub March 30, 2011].
6.         Choi K-H, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman A, Walsh J, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han M-H, Self DW  (2011)  Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine.  J Neurosci  32(21):7927-7937.
7.         Lester BM, Tronick E, Nestler E, Abel T, Kosofsky B, Kuzawa CW, Marsit CJ, Maze I, Meaney MJ, Monteggia LM, Reul JM, Skuse DH, Sweatt JD, Wood MA  (2011)  Behavioral epigenetics.  Ann N Y Acad Sci  1226(1):14-33.
8.         Nelson ED, Kavalali ET, Monteggia LM (2011)  Selective Impact of MeCP2 and associated Histone
Deacetylases on the Dynamics of Evoked Excitatory Neurotransmission.  J Neurophysiol 106(1):193-201.
9.         Autry A. E., Adachi M., Nosyreva E, Na ES, Los MF, Cheng P, Kavalali, ET, Monteggia LM (2011) NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses.  Nature  275(7354):91-95.
10.       Autry AE, Monteggia LM (in press)  BDNF and Neuropsychiatric Disorders.  Pharmacological Reviews


1.         Autry AE, Monteggia LM (2010)  Contribution of BDNF to higher incidence of depression-related behavior in females.  US Psychiatry  3(1).
2.         Morris MJ, Karra AS, Monteggia LM (2010) Histone deacetylases govern cellular mechanisms underlyng behavioral and synaptic plasticity in the developing and adult brain.  Behav Pharmacol  21(5-6):409-419.


1.         Monteggia LM, Kavalali ET (2009) Rett Syndrome and the Impact of MeCP2 Associated Transcriptional Mechanisms on Neurotransmission.  Biol Psychiatry  65(3):204-210
2.         Autry AE, Adachi M, Cheng P, Monteggia LM (2009) Gender Specific Impact of BDNF signaling on Stress-Induced Depression-Like Behavior.  Biol Psychiatry, 66(1):84-90.
3.         Adachi M, Autry AE, Covington HE 3rd, Monteggia LM (2009) MeCP2-mediated Transcription Repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett Syndrome.  J Neurosci 29(13):4218-4227.
4.         Akhtar MW, Raingo J, Nelson ED, Montgomery RL, Olson EN, Kavalali ET, Monteggia LM (2009)  Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function.  J Neurosci 29(25):8288-97. 
5.         Autry AE, Monteggia LM  (2009) Epigenetics in suicide and depression. Biol Psychiatry, 66:812-813.
6.         Adachi M, Monteggia LM (2009) Synergistic Interactions between Histone Deacetylase Inhibitors and Drugs of Abuse.  Neuropsychopharmacology, 34(13):2619-2620.


1.         Adachi M, Barrot M, Autry A, Theobald D, Monteggia LM (2008)  Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63:642-649.
2.         Monteggia LM  (2008)  Synaptic dysfunction in Rett Syndrome, an Autism Spectrum Disorder.  8Neuropsychopharm  33(1):205.
3.          Nelson ED, Kavalali ET, Monteggia LM (2008) Activity-dependent suppression of miniature
            neurotransmission through the regulation of DNA methylation.  J Neurosci  28(2):395-406.
4.         Malberg JE, Monteggia LM (2008)  VGF, a new player in antidepressant action?  Sci Signal 1, pe19.
5.         Bachtell RK, Cho K-H, Monteggia LM, Neve RL, Self DW (2008)  Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior.  Eur J Neurosci  27(9):2229-2240.
6.         Barbosa AC, Kim M-S, Ertunc M, Adachi M, Nelson ED, McAnally J, Richardson JA, Kavalali ET, Monteggia LM, Bassel-Duby R, Olson EN  (2008)  MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci 105(27):9391-9396.
7.         Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA Jr, Cook EH Jr, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R  (2008)  It is time to take a stand for medical research and against terrorism targeting medical scientists.  Biol Psychiatry  63(8):725-727.


1.         Monteggia LM, Luikart B, Barrot M, Nef S, Parada LF, Nestler EJ.  (2007)  BDNF Conditional
Knockouts Show Gender Differences in Depression Related Behaviors. Biol Psychiatry, 61(2):187-197.
2.         Hensler JG, Advani T, Monteggia LM  (2007) Regulation of 5-HT1A receptor function in inducible BDNF knock-out mice following administration of corticosterone. Biol Psychiatry 62(5):521-529.
3.         Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM  (2007) Long Term Behavioral & Molecular Alterations Associated with Maternal Separation in Rats. Eur J Neurosci 25(10)3091-3098.
4.         Becker JB, Monteggia LM, Perrot-Sinal T, Romeo R, Taylor J, Yehuda R, Bale T  (2007) Stress and Disease: Is Being Female a Predisposing Factor?  J Neurosci  27(44):11851-11855.
5.         Monteggia LM (2007)  Elucidating the role of brain derived neurotrophic factor (BDNF) in brain.  Am J Psychiatry  164(12):1790.


1.         Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA, Mirnics K  (2006)  Specificity & timing of BDNF regulation of neocortical gene expression. Mol Psychiatry 11(7):633-648.
2.         Duman RS, Monteggia LM  (2006)  A Neurotrophic Model for Stress-Related Mood Disorders. 
Biol Psychiatry  59(12):1116-1127  [Epub April 19].
3.         Berton, O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ  (2006)  Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress.  Science, 311:864-868.
4.         Mahgoub MA, Sara Y, Kavalali ET, Monteggia LM  (2006) Reciprocal interaction of activity and 5-HT in regulation of CRE-dependent gene expression. J Pharmacol Exp Ther 317(1):88-96.
5.         Gemelli T, Berton O, Nelson E, Perroti LI, Jaenisch R, Monteggia LM  (2006)  Postnatal loss
of MeCP2 in the forebrain is sufficient to mediate behavioral aspects of Rett Syndrome in mice.
Biol Psychiatry, 59(5):468-476. 
6.         Nelson E, Kavalali ET, Monteggia LM  (2006)  MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Current Biology  16:710-716.


1.         Waugh JL, Lou AC, Eisch AJ, Monteggia LM, Nestler EJ, Muly EC, Gold SJ (2005)  Regional, Cellular and Subcellular Localization of RGS10 in Rodent Brain.  J Comp Neurol,  481(3):299-313.
2.         Hashimoto T, Bergen SE, Nguyen QL, Xu B, Monteggia LM, Pierri JN, Sun Z, Sampson AR, Lewis DA  (2005)  Relation of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia,  J Neurosci  25(2):372-383.
3.         Hill JJ, Kolluri N, Hashimoto T, Wu Q, Sampson AR, Monteggia LM, Lewis DA  (2005)  Analysis of
Pyramidal Neuron Morphology in an Inducible Knockout of Brain Derived Neurotrophic Factor.  Biol Psychiatry  57(8):932-934.
4.         Yu TS, Dandekar M, Monteggia LM, Parada LF, Kernie SG  (2005)  Temporally regulated expression    of Cre recombinase in neural stem cells.  Genesis  41(4):147-153.


1.       Powell CM, Schoch S, Monteggia L, Barrot M, Matos MF, Feldmann N, Südhof TC, Nestler EJ (2004)  The Presynaptic Active Zone Protein RIM1a is Critical for Normal Associative Learning.  Neuron 42:143-153.
2.       Monteggia LM, Barrot M, Powell C, Berton O, Galanis V, Nagy A, Greene RW, Nestler EJ (2004)  Essential Role of BDNF in Adult Hippocampal Function and Depression.  Proc Natl Acad Sci, 101(29):10827-10832.
3.       Perrotti LI, Hadeishi Y, Ulery PG, Barrot M, Monteggia LM, Duman RS, Nestler EJ  (2004)  Induction of  DFosB in reward-related brain structures after chronic stress.  J Neurosci  24(47):10594-602.