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Adult Protocols

Brain tumor researchers are constantly looking for new ways of effectively treating this disease. Clinical trials are programs for testing new medications and treatments. The earliest studies of a new treatment are called Phase I trials. They try to determine the highest safe dose of a new medication. Phase II trials try to determine if the drug is effective.  Phase III trials compare the new treatment with current treatments.

The North American Brain Tumor Consortium (NABTC) is a group of research facilities through out the US dedicated to finding new treatments for brain tumors.

• IRB # 0803 521
  Endotecarin for Relapsed Glioblastoma Multiforme
  Phase III, Randomized, Open-Label, Efficacy and Safety Study of Intravenous Edotecarin Versus Either Temozolomide or Carmustine (BCNU) in Patients with Glioblastoma Multiforme That Has Progressed or Recurred After Prior Alkylator-based Adjuvant Chemotherapy
• Eligibility: Histologically confirmed GBM that has progressed after surgery, radiation therapy and chemotherapy with either CCNU, BCNU or temozolomide.  Progressive Disease based on an MRI scan obtained within 14 days prior to randomization.
   

Last updated: May 29, 2007