Immunobiology of Uveal Melanoma
Human Uveal Melanoma Liver Metastases Liver Metastases (microscopic)
Uveal Melanoma is the most common and malignant ocular tumor in adults. The 5-year survival time for uveal melanoma patients has not improved in over 30 yr.
- What is the basis for increased liver metastases of intraocular melanomas in aged versus young mice?
- What are the mechanisms invoked by NKT cells that disable NK cell-mediated cytolytic function in the liver and exacerbate metastasis of intraocular melanomas?
- What role do tumor-associated neutrophils (TAN) play in the development of liver metastases arising from intraocular melanomas?
Animal Models and Research Tools
- NOD/SCID model of human uveal melanoma.
- Panel of 10 human uveal melanoma cell lines and 3 liver metastases cell lines including OCM-3-GFP human uveal melanoma cell line that expresses green fluorescent protein.
- siRNA for inhibiting CXCR4 chemokine receptor expression is used for “proof of principle” studies on the role of chemokine receptors in the formation of liver metastases.