Olson Laboratory

UTSW Moleculare Biology




Selected Publications

  1. Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell, 83: 1125-1136.
  2. Fishman, M.C. and Olson, E.N. 1997. Parsing the Heart: Genetic modules for organ assembly. Cell, 91: 153-156.
  3. Molkentin, J.D., Lu, J., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S. and Olson, E.N. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell, 93: 215-228.
  4. Olson, E.N., and Williams, R.S. 2000. Calcineurin signaling and muscle remodeling. Cell, 101: 689-692.
  5. Srivastava, D., and Olson, E.N. 2000. A genetic blueprint for cardiac development: Implications for human heart disease. Nature, 407: 221-226.
  6. McKinsey, T.A., Zhang, C.L., Lu, J., and Olson, E.N. 2000. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature, 408: 106-111.
  7. Wang, D-Z., Chang, P., Wang, Z., Small, E., Krieg, P.A., Olson, E.N. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell, 105: 851-862.
  8. Chen E.H., Olson E.N. 2001 Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila.  Developmental Cell. 1, 705-715.
  9. Yanagisawa, H., Davis, E.C., Starcher, B.C., Ouchi, T., Yanagisawa, M., Richardson, J.A. and Olson, E.N. 2002. Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo. Nature, 415: 168-171.
  10. Zhang, C.L., McKinsey, T.A., Chang, S., Antos, C.A., Hill, J.A., and Olson, E.N. 2002. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell, 110: 479-488.
  11. Shin, C.H., Liu, Z.P., Passier, R., Zhang, C.L., Wang, D.Z., Harris, T.M., Yamagishi, H., Richardson, J.A., Childs, G., and Olson, E.N. 2002. Modulation of cardiac development by HOP, an unusual homeodomain that antagonizes the activity of serum response factor. Cell, 110: 725-735.
  12. Lu, J., Hawkins, A.F., Bassel-Duby, R., Richardson, J.A., and Olson, E.N. 2002. Control of facial muscle development by MyoR and capsulin. Science, 298: 2378-2381.
  13. Naya, F.J., Black, B.L., Wu, H., Bassel-Duby, R., Richardson, J.A., Hill, J.A., Olson, E.N. 2002. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nature Medicine, 8, 1303-1309.
  14. Sosic, D., Richardson, J.A., Yu, K., Ornitz, D.M., and Olson, E.N. 2003. Twist genes regulate cytokine expression and energy homeostasis through a negative feedback loop that represses NF-B activity. Cell, 112: 169-180.
  15. Chen, E.H., Pryce, B.A., Tzeng, J.A., Gonzalez, G., and Olson, E.N. 2003. Control of myoblast fusion by a guanine nucleotide exchange factor, Loner, and its effector ARF6. Cell, 114: 751-762.
  16. Olson, E.N., and Schneider, M.D. 2003. Sizing up the heart: development redux in diseases. Genes & Development, 17, 1937-1956.
  17. Wang, Z., Wang, D-Z., Hockemeyer, D., McAnally, J., Nordheim, A., and Olson, E.N. 2004. Myocardin and ternary complex factors compete for SRF during smooth muscle development. Nature, 428: 185-189.
  18. Frey N., Barrientos T., Shelton J.M., Frank D., Rutten H., Gehring D., Kuhn C., Lutz M., Rothermel B., Bassel-Duby R., Richardson J.A., Katus H.A., Hill J.A., Olson E.N. 2004. Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nature Medicine, 10, 1336-1343.
  19. Olson, E.N. 2004. A decade of discoveries in cardiac biology. Nature Medicine, 10, 467-474.
  20. Vega, R.B., Matsuda, K., Oh, J., Barbosa, A., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J.M., Richardson, J.A., Karsenty, G., and Olson, E.N. 2004. Histone deacetylase 4 controls chondrocyte hypertrohy during skeletogenesis. Cell, 119: 555-566.
  21. Liu, Z-P., Wang, Z., and Olson, E.N. 2005. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Developmental Cell, 9, 261-270.
  22. Nakagawa, O., Arnold, M., Nakagawa, M., Hamada, H., Shelton, J.M., Kusano, H., Harris, T.M., Childs, G., Campbell, K.P., Richardson, J.A., Nishino, I., and Olson, E.N. 2005. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes & Development, 19, 2066-2077.
  23. Chen, E.H. and Olson, E.N. 2005. Unveiling the mechanisms of cell-cell fusion. Science, 308: 369-373.
  24. Bassel-Duby, R. and Olson, E.N. 2006. Signaling pathways in skeletal muscle remodeling. In Annual Review of Biochemistry, 75: 19-37.
  25. Song, K., Backs, J., McAnally, J., Qi, S., Richardson, J.A., Hill, J.A., Bassel-Duby, R., and Olson, E.N. 2006. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell, 125: 453-466.
  26. Chang, S., Young, B.D., Li, S., Qi, X., Richardson, J.A., Olson, E.N. 2006. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell, 126: 321-334.
  27. Olson E.N. 2006. Gene regulatory networks in the evolution and development of the heart. Science, 313: 1922-1927.
  28. Yi P., Han Z., Li X., Olson E.N.   The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science. 2006 Sep 1;313(5791):1301-3.
  29. Arnold M.A., Kim Y., Czubryt M.P., Phan D., McAnally J., Qi X., Shelton J.M., Richardson J.A., Bassel-Duby R., Olson E.N. 2007 MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Developmental Cell, 12: 377-389.
  30. van Rooij E., Sutherland L.B., Qi X., Richardson J.A., Hill J., Olson E.N. 2007. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science, 316: 575-579.
  31. van Rooij E., Olson E.N. 2007. MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets.The Journal of Clinical Investigation, 117:2369-76.
  32. Mongomery R.L., Davis C.A., Potthoff M.J., Haberland M., Fielitz J., Qi X., Hill J.A., Richardson J.A., Olson E.N. 2007. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes & Development, 21(14): 1790-802.
  33. Shusheng Wang, Arin B. Aurora, Brett A. Johnson, Xiaoxia Qi, John McAnally, Joseph A. Hill, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson. 2008. The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis. Developmental Cell, 15: 261–271.
  34. Yi P, Johnson AN, Han Z, Wu J, Olson EN. 2008. Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Developmental Cell, 15(5):704-13.
  35. Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R and Olson EN. 2008. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes & Development, 22(23): 3242-54.
  36. Haberland M, Mokalled MH, Montgomery RL, Olson EN. 2009. Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes & Development, 23(14):1625-30.
  37. Haberland M, Montgomery RL, Olson EN. 2009. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet, 10(1):32-42. Review.
  38. Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN. 2009. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev., 23(18):2166-78. Epub 2009 Aug 31.
  39. van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. 2009. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell., 17(5):662-73.
  40. Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN. 2009. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science., 326(5959):1549-54.
  41. Ning Liu and Eric N. Olson. 2010. MicroRNA Regulatory Networks in Cardiovascular Development. Developmental Cell., 18(4):510-525.
  42. David M. Patrick, Cheng C. Zhang, Ye Tao, Huiyu Yao, Xiaoxia Qi, Robert J. Schwartz, Lily Jun-Shen Huang, and Eric N. Olson. 2010. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ. Genes & Development, 24: 1614-1619.
  43. Mark E. Hatley, David M. Patrick, Matthew R. Garcia, James A. Richardson, Rhonda Bassel-Duby, Eva van Rooij and Eric N. Olson. 2010. Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21. Cancer Cell, 18(3): 282-293.
  44. Viviana Moresi, Andrew H. Williams, Eric Meadows, Jesse M. Flynn, Matthew J. Potthoff, John McAnally, John M. Shelton, Johannes Backs, William H. Klein, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson. 2010. Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases. Cell, 143(1): 35-45.
  45. Olson EN, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. 2010 May. Nat Rev Mol Cell Biol, 11(5):353-65. Review.
  46. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. 2011. Transient regenerative potential of the neonatal mouse heart. Science, 331(6020):1078-80.
  47. Small EM, Olson EN. 2011. Pervasive roles of microRNAs in cardiovascular biology. Nature, 469(7330):336-42. Review.
  48. Mendell JT, Olson EN. 2012 Mar 16. MicroRNAs in Stress Signaling and Human Disease. Cell, 148(6):1172-87.
  49. Grueter CE, van Rooij E, Johnson BA, Deleon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN. 2012 Apr 27. A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13. Cell, 149, 671-83 (2012).
  50. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. 2012 May 13. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature, 485(7400):599-604.
  51. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. 2012 Decmeber 21. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science, 338(6114):1599-603.
  52. Eva van Rooij & Eric N. Olson. November 2012. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nature Reviews Drug Discovery 11, 860-872.
  53. Millay DP, O'Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN. July 18 2013. Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature, 499(7458):301-5. doi: 10.1038/nature12343.
  54. Xin M, Olson EN, Bassel-Duby R. August 2013. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nature Reviews Molecular Cell Biology, 14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10.
  55. Olson EN. June 4, 2014. MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease. Science Translational Medicine, 6(239):239ps3. DOI: 10.1126/scitranslmed.3009008.
  56. Douglas P. Millay, Lillian B. Sutherland, Rhonda Bassel-Duby, Eric N. Olson. August 1, 2014. Myomaker is essential for muscle regeneration. Genes & Development, 28: 1641-1646; doi:10.1101/gad.247205.114.
  57. Chengzu Long, John R. McAnally, John M. Shelton, Alex A. Mireault1, Rhonda Bassel-Duby, Eric N. Olson. September 5, 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA. Science, 345 (6201): 1184-1188; DOI: 10.1126/science.1254445.
  58. Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN. Feb 12, 2015. A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance. Cell, 160(4):595-606. doi: 10.1016/j.cell.2015.01.009. Epub 2015 Jan 29.
  59. Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, Reese AL, McAnally JR, Chen X, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN. Jan 15, 2016. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science, 351(6270):271-5. doi: 10.1126/science.aad4076.
  60. Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN. Jan 22, 2016. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science, 351(6271):400-403. doi: 10.1126/science.aad5725.
  61. Amoasii1 L, Holland W, Sanchez-Ortiz E, Baskin KK, Pearson M, Burgess SC, Nelson BR, Bassel-Duby1 R, Olson EN. Feb 15, 2016. A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism. Genes & Dev., 30(4):434-446. doi: 10.1101/gad.273128.115.
  62. Kelly M. Anderson, Douglas M. Anderson, John R. McAnally, John M. Shelton, Rhonda Bassel-Duby & Eric N. Olson. Nov 17, 2016. Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature, 539:433-436. doi:10.1038/nature20128.
  63. Douglas M. Anderson, Catherine A. Makarewich, Kelly M. Anderson, John M. Shelton, Svetlana Bezprozvannaya, Rhonda Bassel-Duby, and Eric N. Olson. Dec 6, 2016. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Science Signaling, Vol. 9, Issue 457, pp. ra119 DOI: 10.1126/scisignal.aaj1460.
  64. Liu N, Garry GA, Li S, Bezprozvannaya S, Sanchez-Ortiz E, Chen B, Shelton JM, Jaichander P, Bassel-Duby R, Olson EN. March 2017. A Twist2-dependent progenitor cell contributes to adult skeletal muscle. Nat Cell Biol., 19(3):202-213. doi: 10.1038/ncb3477. Epub 2017 Feb 20.
  65. Zhang Y, Long C, Li H, McAnally JR, Baskin KK, Shelton JM, Bassel-Duby R, Olson EN. April 12, 2017. CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice. Sci Adv., 3(4):e1602814. doi: 10.1126/sciadv.1602814. eCollection 2017 Apr.
  66. Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN. April 21, 2017. Control of muscle formation by the fusogenic micropeptide myomixer. Science., 356(6335):323-327. doi: 10.1126/science.aam9361. Epub 2017 Apr 6.