Publications
2012
- Krachler AM & Orth K. In vitro characterization of Multivalent Adhesion Molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel. Virulence (2012) (In Press)
- Alto, N.M. & Orth, K. Subversion of cell signaling by pathogens. In Signal Transduction Textbook. Cold Spring Harbor Press (2012).
- Zhang, L.L, Krachler, A-M, Broberg, CA, Li, Y, Mirzaei, H, Gilpin, CJ & Orth, K. Type III effector VopC mediates invasion for Vibrio species. Cell Reports (2012) 1(5): 453-460.
- Rahman, M., Ham, H., Liu, X., Sugiura, Y., Orth, K. and Krämer, H. Visual neurotransmission in Drosophila requires expression of dFic in glial capitate projections. Nature Neuroscience (2012) Apr 29. doi: 10.1038/nn.3102. [Epub ahead of print] PMID:22544313.
- Krachler, A-M, Ham, H. & Orth, K. Turnabout is fair play: Use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence (2012) 1;3(1).
2011
- Krachler AM & Orth K. Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands. J Biol Chem. (2011) Nov 11;286(45):38939-47.
- Grammel M, Luong P, Orth K, Hang HC. A chemical reporter for protein AMPylation. J Am Chem Soc. (2011) Nov 2;133(43):17103-5.
- Krachler, A-M, Woolery, A.R. & Orth, K. Host-pathogen interactions: Manipulation of kinase signaling by bacterial pathogens. (2011) J. Cell Biol 195(7):1083-92.
- Krachler AM, Ham H, Orth K. The outer membrane adhesion factor MAM7 initiates host cell binding during infection with Gram-negative pathogens. (2011) Proc Natl Acad Sci USA. Epub June 2011.
- Ham H., Sreelatha, A. & Orth, K. (2011) Manipulation of Host Membranes by Bacterial Effectors. Nature Reviews Microbiology 9(9):635-46.
- Broberg, CA, Calder, TJ, & Orth, K. Vibrio parahaemolyticus cell biology and pathogenicity determinants. Microbes Infect. 2011 Nov;13(12-13):992-1001. Epub 2011 Jul 7.
- Hao YH, Chuang T, Ball HL, Luong P, Li Y, Flores-Saaib RD, Orth K. Characterization of a rabbit polyclonal antibody against threonine-AMPylation. (2011) J Biotechnol. 151(3):251-4.
- Li Y, Al-Eryani R, Yerbrough ML, Orth K, Ball HL. Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry. (2011) J Am Soc Mass Spectrom. 22(4):752-61.
- Krachler AM, Orth K. Black Spot, Black Death, Black Pearl: Tales of Bacterial Effectors. Chapter in Avancées et nouvelles technologies en Toxinologie – Advances and new technologies in Toxinology (SFET, ed.). ISSN 1760 – 6004.
2010
- Broberg CA, Zhang L, Gonzalez H, Laskowski-Arce MA, Orth K. A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity. (2010) Science. 329(5999):1660-2.
- Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. (2010) J Biol Chem. 285(26):20155-63.
- Broberg CA, Orth K. Tipping the balance by manipulating post-translational modifications. (2010) Curr Opin Microbiol. 13(1):34-40.
- Woolery AR, Luong P, Broberg CA, Orth K. AMPylation: Something Old is New Again. (2010) Front Microbiol. 1:113.
2009
- Burdette DL, Seemann J, Orth K. Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis. (2009) Mol Microbiol. 73(4):639-49.
- Kinch LN, Yarbrough ML, Orth K, Grishin NV. Fido, a novel AMPylation domain common to fic, doc, and AvrB. (2009) PLoS One. 4(6):e5818.
- Yarbrough ML, Orth K. AMPylation is a new post-translational modification. (2009) Nat Chem Biol. 5(6):378-9.
- Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (2009) Science. 323(5911):269-72.
- Burdette DL, Yarbrough ML, Orth K. Not without a cause: Vibrio parahaemolyticus induces acute autophagy and cell death. (2009) Autophagy. 5(1):100-2.
2008
- Mukherjee S, Orth K. Microbiology. A protein pupylation paradigm. (2008) Science. 322(5904):1062-3.
- Laskowski-Arce MA, Orth K. Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus. (2008) Appl Environ Microbiol. 74(23):7183-8.
- Burdette L, Yarbrough ML, Orvedahl A, Gilpin CJ, Orth K. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. (2008) Proc Natl Acad Sci USA. 105(34):12497-502.
- Mukherjee S, Orth K. in vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ. (2008) Methods Enzymol. 438:343-53.
- Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC. Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. (2008) J Immunol. 180(7):5045-56.
- Mukherjee S, Negi VS, Keitany G, Tanaka Y, Orth K. In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax. (2008) J Biol Chem. 283(22):15127-33.
- Hao YH, Wang Y, Burdette D, Mukherjee S, Keitany G, Goldsmith E, Orth K. Structura requirements for Yersinia YopJ inhibition of MAP kinase pathways. (2008) PLoS One. 3(1):e1375.
- Trosky JE, Liverman AD, Orth K. Yersinia outer proteins: Yops. (2008) Cell Microbiol. 10(3):557-65.
2007 & earlier
Pubmed