Publications

  • Burdette, D., Seemann, J. & Orth, K. Vibrio VopQ Induces PI3-Kinase Independent Autophagy and Antagonizes Phagocytosis. Molecular Microbiology. In Press.

  • Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (2009) Science. 323: 269-272. (Epub, Nov. 2008).

  • Burdette, D., Yarbrough, M. & Orth, K. Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death. (2009) Autophagy 5; 100-102 . (Epub, Nov. 2008).

  • Hao, Y-H., Wang, Y., Burdette, D., Mukherjee, S., Keitany, G., Goldsmith, E., and Orth, K. Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways. (2008) PLoS ONE 1: 1-9 e1375.

  • Mukherjee, S. and Orth, K. In vitro signaling by MAPK and NFkB pathways inhibited by Yersinia YopJ. (2008) Methods in Enzymology 438: 343-353.

  • Burdette, D., Yarbrough, M., Orvedahl, A., Gilpin, C. & Orth, K. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding and then cell lyses. (2008) PNAS USA 105: 12497-12502.

  • Laskowski-Arce, M.A. and Orth, K. A molecular conversation between a protozoan predator and a food-borne bacterial pathogen. (2008) Applied and Environmental Microbiology. 74: 7183-7188.

  • Trosky, J. E., Li, Y., Mukherjee, S., Keitany, G., Ball, H. and Orth, K. VopA Inhibits ATP binding by Acetylating the Catalytic Loop of MKKs. (2007) J. Biol. Chem. 282: 34299-34305.

  • Liverman, A.D.B., Cheng, H-C., Trosky, J., Leung, D.W., Melanie L. Yarbrough, Dara L. Burdette, Michael K. Rosen & Orth, K. Direct Assembly of Actin by Vibrio Type III Effector VopL. (2007) PNAS USA 104: 17117-17122.

  • Mukherjee, S., Hao, Y-H., and Orth, K. New posttranslational modification on Ser/Thr residues by acetylation (2007) Trends in Biochemical Sciences 32: 210-216.

  • Chosed, R., Tomchick, D.R., Brautigam, C.A., Machius, M.2, & Orth, K. Structural analysis of Xanthomonas XopD provides insights into substrate specificity of Ulp1s. (2007) J. Biol. Chem. 282:6773-6782.

  • Chosed, R., Mukherjee, S. & Orth, K. Impact of regulatory domains on activity and specificity of Arabidopsis thaliana Ulp1s. (2006) Biochemical J., 398, 521-529.

  • Mukherjee, S. Kietany, G., Li, Y Wang, Y., Hall B.E., Goldsmith, E & Orth, K. Yersinia YopJ Acetylates and Inhibits Kinase Activation by Preventing Phosphorylation. (2006) Science, 312:1211-1214.

  • Trosky, J., Mukherjee, S., Burdette, D., Roberts, M., McCarter, L., Siegel, R. & Orth, K. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. (2004) J. Biol. Chem., 279, 51953-51957.

  • Hotson, A., Chosed, R., Shu, H., Orth, K., Mudgett, M.B. (2003) Xanthomonas Type III Effector XopD Targets SUMO-conjugated Proteins in planta. Molecular Microbiology. Manuscript in Press.

  • Yoon, S., Lui, Z., Eyobo, Y. & Orth, K. (2003) Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism. J. Biol. Chem., 278, 2131-2135.

  • Orth, K. (2002) Yersinia effector YopJ is an Ubiquitin-like protein protease. Current Opinions in Microbiology, Vol. 31, 361-376.

  • Orth, K., Xu, Z., Mudgett, M.B., Bao, Z.Q., Mangel, W.F., Staskawicz, B. & Dixon, J.E. Yersinia effector YopJ is a Ubiquitin-like protein protease that disrupts signaling. (2000) Science, 290, 1594-1597.

  • Juris, S.J., Rudolph, A.E., Huddler, D., Orth, K. & Dixon, J.E. (2000) A novel role for the Yersinia protein kinase: actin binding, kinase activation and cytoskeleton disruption. Proceedings of the National Academy of Sciences of the United States of America, 97, 9431-9436.

  • Orth, K., Palmer, L.P., Zhao Qin Bao, Z.Q.,Stewart, S., Rudolph, A., Bliska, J.B. & Dixon, J.E. (1999) A Yersinia Virulence Factor Inhibits Activation of the Mitogen Activated Protein Kinase Kinase Superfamily. Science, 285, 1920-1923.