Orth Lab

Research

Vibrio parahaemolyticus T3SS2

The second pathogenicity island of Vibrio parahaemolyticus contains T3SS2 and is associated with enterotoxicity. We have identified the activity of two effectors on this island. The first, VopA, is a homologue of Yersinia YopJ and also displays acetylatransferase activity (Trosky et al., J Biol Chem 2007). Another effector, VopL, during infection promotes the assembly of actin stress fibers and in vitro, recombinant VopL potently induces assembly of actin filaments that grow at their barbed ends, independent of eukaryotic factors (Liverman et al., PNAS USA 2007).

 

Publications on T3SS2