Orth Lab

Research

YopJ and Ser/Thr Acetylation

Studies in my lab focused on YopJ, a bacterial effector expressed by Yersinia. This pathogen, the causal agent of the Plague, uses YopJ to shut down the signaling machinery responsible for eliciting an immune response. We discovered that YopJ uses a novel post-translational modification, Ser/Thr acetylation to modify kinases and prevent their activation by phosphorylation (Science. 323:269-272, 2009).

 

Publications on AMPylation