Welcome to the Pasare Lab

Dept. of Immunology, NA7.201

Univ. of Texas Southwestern Med. Ctr.

6000 Harry Hines Blvd.

Dallas, TX 75390-9093

Office Phone: 214-648-7322

Lab Phone: 214-648-7323

E-mail: Chandrashekhar.pasare@utsouthwestern.edu

 
 

Welcome to the Pasare Lab homepage. The major research interests of our lab involve studying the Toll-like receptor signaling pathway and how activation of Toll-like receptors influence shaping of the adaptive immune responses. Toll-like receptors are a major family of receptors of the innate immune system. These receptors sense the presence of bacterial, fungal and viral pathogens. During an infection, Toll-like receptors get activated on macrophages and dendritic cells, leading to secretion of cytokines and chemokines that are important for protection against pathogens. Dendritic cells in turn activate antigen specific T cells, which help in eliminating the pathogen, as well as protect us in event of re-infection with the same bacteria or virus. This is in fact the basis for vaccination. Our lab is interested in understanding how Toll-like receptors recognize Gram positive bacteria, Gram negative bacteria, RNA viruses and DNA viruses, and then help activate T cells that are specific to all these different types of pathogens. In addition we are also interested in understanding how the Toll-like receptor signaling pathway is regulated inside a cell to dampen inflammatory responses. We are investigating molecular mechanisms by which proteins inside the cell control the Toll-like receptor signaling pathway. In many cases, over-activation of the Toll-like receptor signaling pathway leads to chronic inflammation and auto-immune diseases such as rheumatoid arthritis and lupus.

 

Pictured left to right:  Chandrashekhar Pasare, Rajakumar Mandaraju, Wei Hu,  Travis Brewer, Aakansha Jain and Ty Troutman.