The Rogers NMR Center Mouse Metabolic Phenotyping Center specializes in the use of stable isotopes for investigations of metabolism, including a comprehensive analysis of gluconeogenesis.
Our goal is to provide a repertoire of metabolic analyses that can be standardized and used to phenotype mouse models of type 2 diabetes. These tools are based on new concepts for probing intermediary metabolism using 13C- or 2H-enriched compounds. In some instances the studies are simple enough to perform in the referring investigator's lab; only partially processed tissue samples need be shipped to the Rogers NMR Center for full analysis.
The Rogers NMR Center Mouse Metabolic Phenotyping Center at UT Southwestern is one of four such MMPC centers, sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). These centers provide investigators access to state-of-the-art methodology for probing metabolism in mouse models of disease generated by genetic manipulation. |
