Mouse Phenotyping
The Rogers NMR Center Mouse Metabolic Phenotyping Center
specializes in the use of stable isotopes for investigations of
metabolism, including a comprehensive analysis of
gluconeogenesis.
Our goal is to provide a repertoire of metabolic analyses that
can be standardized and used to phenotype mouse models of type 2
diabetes. These tools are based on new concepts for probing
intermediary metabolism using 13C- or
2H-enriched compounds. In some
instances the studies are simple enough to perform in the
referring investigator's lab; only partially processed tissue
samples need be shipped to the Rogers NMR Center for full
analysis.
The Rogers NMR Center Mouse Metabolic Phenotyping Center at UT
Southwestern is one of four such MMPC centers, sponsored by the
National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK). These centers provide investigators access to
state-of-the-art methodology for probing metabolism in mouse
models of disease generated by genetic manipulation.
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