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Thursday, May 6, 1999
Presented by:
The Mary Nell and Ralph B. Rogers
Magnetic Resonance Center
and
The National Center for Research Resources
Program Objective | Guest Speakers | UT Southwestern Speakers | Program Schedule | Corporate Sponsors
Program Objective
This symposium brings together research from laboratories at UT
Southwestern and our outstanding guest speakers. The morning
session is devoted to training for physicians, biomedical
scientists and students who are interested in
13C NMR isotopomer analysis for metabolic
studies. In this session, Dr. Dean Sherry will present
an overview of basic concepts for 13C NMR
isotopomer analysis, Dr. Craig Malloy will discuss extracting
metabolic information from NMR data, Dr. Thomas Szyperski
will present the use of 2D techniques, and Dr. Robert
Lenkinski will discuss the application of 1H
NMR to in vivo metabolic studies.
The afternoon session focuses on 13C NMR and
13C Mass Spectrometry in research on
intermediary metabolism. Dr. Gary Lopaschuk will
discuss the heart with Dr. Denis McGarry presenting
applications to the liver. Following these presentations,
Dr. Christopher Newgard, Dr. Marc Hellerstein, and
Dr. John Jones will present their applications to
intermediary metabolism.
The reception and dinner is designed to provide an opportunity for
interaction between attendees and speakers. After dinner,
Dr. Henri Brunengraber from Case Western Reserve University
will discuss the use of metabolic studies in medical decisions.
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Guest Speakers
Thomas Szyperski, Ph.D., Associate Professor of Chemistry and
Biochemistry, State University of New York at Buffalo, Buffalo, NY
Robert E. Lenkinski, Ph.D., Professor of Radiologic Science,
Magnetic Resonance Imaging, Department of Radiology, University of
Pennsylvania Medical Center, Philadelphia, PA
Gary Lopaschuk, Ph.D., Professor of Pediatrics, Adjunct Professor
of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Marc Hellerstein, M.D., Ph.D Associate Professor in Nutritional
Sciences, University of California at Berkeley, and Associate
Professor of Medicine, University of California at San Francisco
Henri Brunengraber, M.D., Ph.D Chair and Professor, Department of
Nutrition, Case Western Reserve University, Cleveland, OH
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UT Southwestern Speakers
A. Dean Sherry, Ph.D., Professor of Radiology at the University of
Texas Southwestern Medical Center and Professor of Chemistry at the
University of Texas at Dallas
Craig R. Malloy, M.D., Professor of Radiology and Internal
Medicine, and Director of the Southwestern Biomedical Magnetic
Resonance Facility at the Mary Nell and Ralph B. Rogers Magnetic
Resonance Center, University of Texas Southwestern Medical Center,
Dallas, Texas
J. Denis McGarry, Ph.D., Professor of Internal Medicine and
Biochemistry, University of Texas Southwestern Medical Center,
Dallas, TX
Christopher B. Newgard, Ph.D., Professor of Biochemistry and
Internal Medicine, University of Texas Southwestern Medical Center,
Dallas, TX
John G. Jones, D.Sc., Instructor of Radiology, University of Texas
Southwestern Medical Center, Dallas, TX
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Program Schedule
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8:00 a.m. |
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On Site Registration
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TRAINING: INTRODUCTION TO 13C ISOTOPOMERS
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8:30 a.m. |
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How Metabolic Pathways Influence 13C and 1H NMR Spectra
A. Dean Sherry, Ph.D. |
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9:00 a.m. |
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How to Obtain Metabolic Information from 13C and 1H NMR Spectra
Craig R. Malloy, M.D. |
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9:30 a.m. |
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Problem Sets
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10:30 a.m. |
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Break
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10:45 a.m. |
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Indirect Detection of 13C Using 1D 1H and 2D [13C,1H]-Correlation NMR Spectroscopy
Thomas Szyperski, Ph.D. |
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11:30 a.m. |
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Analysis of Metabolic Pathways in vivo by 1H MRS
Robert E. Lenkinski, Ph.D. |
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12:00 a.m. |
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Lunch on your own
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SYMPOSIUM: PROBLEMS IN INTERMEDIARY METABOLISM
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1:00 p.m. |
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Malonyl CoA Control of Fatty Acid Oxidation in the Heart
Gary Lopaschuk, Ph.D. |
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1:45 p.m. |
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Fatty Acid Cross-Talk in the Liver and Pancreatic Beta Cell
J. Denis McGarry, Ph.D. |
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2:30 p.m. |
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Discussion
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2:45 p.m. |
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Break
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3:00 p.m. |
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Genetic Engineering Applied to Metabolic Control Mechanisms
Christopher B. Newgard, Ph.D. |
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3:45 p.m. |
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Quantitation of Metabolic Pathway Fluxes in vivo by GC/MS
Marc Hellerstein, M.D., Ph.D. |
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4:30 p.m. |
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Krebs Cycle Contribution to Gluconeogenesis by NMR
John G. Jones, D.Sc. |
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5:30 p.m. |
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Wine and cheese reception
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6:30 p.m. |
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Buffet dinner
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7:15 p.m. |
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Medical Decisions Based on Metabolic Analysis
Henri Brunengraber, M.D., Ph.D. |
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Corporate Sponsors
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