|
Thursday, May 2, 2002
Presented by:
The Mary Nell and Ralph B. Rogers
Magnetic Resonance Center
and
The National Center for Research Resources
Program Objective | Guest Speakers | UT Southwestern Speakers | Program Schedule
Program Objective
This program is aimed at basic researchers and clinical
investigators with interests in measuring carbohydrate and fat
metabolism in intact animals and patients. Systemic
disorders such as diabetes and obesity have proven difficult to
study due to interactions among multiple biochemical
pathways. Mice are becoming important tools for dissecting
the role of specific genes in health and disease. However,
even simple genetic manipulations may result in a complex
phenotype.
The program introduces new NMR-based methods for analysis of
metabolic networks in mice. Many of these techniques are
applicable in humans. The first session will describe the
principles of 2H and
13C NMR with examples relevant to studies in
mice and in patients. In a second session, guest faculty
will review recent metabolic studies of normal and abnormal mouse
physiology and the relation of these studies to human disease.
Back to top
Guest Speakers
Molly Bogue, Ph.D., Mouse Phenome Project Leader, The Jackson
Laboratory, Bar Harbor, Maine.
Streamson C. Chua, Jr., M.D Ph.D Associate Professor of
Pediatrics, Columbia University, New York, New York..
Robert H. Eckel, M.D., Professor of Medicine, Physiology and
Biophysics, Charles A. Boettcher Endowed Chair in
Atherosclerosis, University of Colorado Health Sciences Center,
Denver, Colorado.
David L. Severson, Ph.D., Professor of Pharmacology and
Therapeutics, University of British Columbia, Vancouver, British
Columbia.
Back to top
UT Southwestern Speakers
Shawn C. Burgess, D.Sc., Research Scientist, Department of
Radiology, UT Southwestern Medical Center at Dallas.
Jay D. Horton, M.D., Assistant Professor of Internal Medicine, UT
Southwestern Medical Center at Dallas.
Craig R. Malloy, M.D., Professor of Radiology and Internal Medicine
and Director of the Southwestern Biomedical Magnetic Resonance
Facility - an NIH-supported research resource at the Mary Nell and
Ralph B. Rogers Magnetic Resonance Center, UT Southwestern Medical
Center at Dallas.
Dean Sherry, Ph.D., Professor of Radiology, UT Southwestern Medical
Center at Dallas and Professor of Chemistry, The University of
Texas at Dallas.
Brian C. Weis, M.D., Ph.D Assistant Professor of Internal
Medicine, UT Southwestern Medical Center at Dallas.
Back to top
Program Schedule
|
8:00 a.m. |
 |
On-Site Registration - North Campus
Continental Breakfast |
|
|
|
8:30 a.m. |
|
Metabolic Fluxes in Humans and Mice
Craig R. Malloy, M.D. |
|
|
|
9:00 a.m. |
|
Analysis of Gluconeogenesis by 2H NMR in the Mouse
Shawn C. Burgess, D.Sc. |
|
|
|
9:30 a.m. |
|
Liver Flux Profiling: Integrated Metabolic Pathways by 2H and 13C NMR
Dean Sherry, Ph.D. |
|
|
|
10:00 a.m. |
|
Discussion
|
|
|
|
10:15 a.m. |
|
Break
|
|
|
|
10:30 a.m. |
|
Intermediary Metabolism in Patients with Liver Disease
Brian C. Weis, M.D., Ph.D. |
|
|
|
11:15 a.m. |
|
Diabetes, Fatty Livers and SREBPs
Jay D. Horton, M.D. |
|
|
|
12:00 a.m. |
|
Catered Lunch
|
|
|
|
1:00 p.m. |
|
Metabolic Assessment in Mice Transgenic for Overexpression of Lipoprotein in Lipase in Muscle
Robert H. Eckel, M.D. |
|
|
|
2:00 p.m. |
|
Metabolism of Perfused Mouse Hearts
David L. Severson, Ph.D. |
|
|
|
3:00 p.m. |
|
Discussion / Break
|
|
|
|
3:15 p.m. |
|
Genetic Manipulations of the Leptin Receptor Gene
Streamson C. Chua, Jr., M.D., Ph.D. |
|
|
|
4:15 p.m. |
|
Using the Mouse and the Mouse Genome to Understand Human Metabolism and Disease
Molly Bogue, Ph.D. |
|
|
Back to top
|
