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Thursday, April 22, 2004
Presented by:
The Mary Nell and Ralph B. Rogers
Magnetic Resonance Center
and
The National Center for Research Resources
Program Objective | Guest Speakers | UT Southwestern Speakers | Program Schedule | Acknowledgments
Program Objective
The goal of the National Institutes of Health-funded Center for
Research Resources at UT Southwestern is to develop novel NMR
technologies for measuring and understanding intermediary
metabolism in vivo. One major emphasis is to use
2H and 13C as metabolic
tracers and modern NMR methodologies to unravel the complexities of
multiorgan metabolism in animals and humans. A second
component of the Center is to develop novel imaging agents that
respond to metabolism in vivo. Given the widespread
interest in Peroxisome Proliferator-Activated Receptors (PPARs) and
exciting recent discoveries in cardiac fat metabolism, the
symposium will provide an update on these topics plus an
introduction to MR methods developed in this Center for quantifying
fat metabolism in the heart.
This year's program is aimed at basic researchers and clinical
investigators with interest in PPARs and the physiology of fat
metabolism in the heart. Although the emphasis this year will
be on the heart, all of the principles in analysis of metabolic
pathways are the same for other organs. The morning session
will review the basics of MR analysis of metabolic fluxes and
conclude with a talk from an established leader in PPARs and their
role in heart metabolism. The afternoon session will begin
with an overview of PPARs and LXRs, followed by discussions of
current studies in clinically relevant models and in humans.
The afternoon will conclude with a discussion of new methods with
the potential for monitoring metabolism by conventional MRI.
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Guest Speakers
Kathleen Brown, D.V.M., Ph.D D.A.C.V.I.M. (Cardiology),
Department of Metabolic Diseases, Glaxo Smith Kline.
Kieran Clarke, Ph.D., Professor of Physiological Biochemistry,
University of Oxford.
Daniel P. Kelly, M.D., Professor of Medicine, Pediatrics, and
Molecular Biology and Pharmacology, Washington University School of
Medicine.
William C Stanley, Ph.D., Associate Professor of Physiology and
Biophysics, Case Western Reserve University.
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UT Southwestern Speakers
Craig R. Malloy, M.D., Professor of Radiology and Internal
Medicine.
Shawn C. Burgess, Ph.D., Assistant Professor of Radiology
David J. Mangelsdorf, Ph.D., Professor of Pharmacology and
Biochemistry.
Matthew E. Merritt, Ph.D., Assistant Professor of Radiology.
Kimberly A. Rosaaen, Ph.D., Postdoctoral Researcher, Department of
Radiology.
A. Dean Sherry, Ph.D., Professor of Radiology, UT Southwestern, and
Chemistry, UT Dallas.
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Program Schedule
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8:00 a.m. |
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On-Site Registration - North Campus
Continental Breakfast |
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8:30 a.m. |
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Energy for the Heart in Health and Disease
Craig R. Malloy, M.D. |
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9:15 a.m. |
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Triglyceride Turnover and Fat Oxidation in the Mouse Heart
Kimberly A. Rosaaen, Ph.D. |
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9:45 a.m. |
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Analysis of Metabolism in Transgenic Mice
Shawn C. Burgess, Ph.D. |
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10:30 a.m. |
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Break
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11:00 a.m. |
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PPAR Signaling in the Regulation of Myocardial Metabolism
Daniel P. Kelly, M.D. |
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12:00 a.m. |
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Catered Lunch
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1:00 p.m. |
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The Role of Nuclear Receptors in Lipid Metabolism
David J. Mangelsdorf, Ph.D. |
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1:45 p.m. |
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PPAR g Activation Alters Glucose and Fatty Acid Uptake and Metabolism: Cardiac Gene Expression and Tracer Studies with [I-125]-BMIPP and [F-18]-2-FDG
Kathleen Brown, Ph.D. |
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2:30 p.m. |
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Regulation of Myocardial Energy Metabolism In Heart Failure
William C. Stanley, Ph.D. |
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3:15 p.m. |
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Discussion / Break
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3:45 p.m. |
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PPAR( Activation Improves Cardiac and Skeletal Muscle Energetics in Type 2 Diabetic Patients
Kieran Clarke, Ph.D. |
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4:30 p.m. |
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The Potential of Molecular Imaging Agents
A. Dean Sherry, Ph.D. |
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5:30 p.m. |
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Wine and Cheese Reception at the A. W. Harris Faculty Club
South Campus |
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Acknowledgments
The photo at top of this page is provided courtesy of Richard
Swaja, Ph.D. and the staff of the National Institute of
Biomedical Imaging and Bioengineering (NIBIB).
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