Laboratory of Elliott M. Ross

Lab Members

Elliott M. Ross
Greer Garson and E.E. Fogelson
Distinguished Chair in Medical Research
Professor, Department of Pharmacology
Graduate Programs in Molecular Biophysics and Cell Regulation
Ph.D., Biochemistry, Cornell University
B.Sc., Biochemistry, University of California, Davis
Faculty Profile
Curriculum Vitae
Teaching Activities
Some thoughts on science

Julia Dyachok
M.S., Biology/Biophysics, Kyiv National Taras Shevchenko University, Ukraine
Ph.D., Biochemistry/Cellular Biology, National Academy of Sciences, Kyiv, Ukraine

Mammalian Target of Rapamycin Complex 1 (mTORC1) coordinates cell growth with the availability of nutrients, including extracellular amino acids. The signaling pathway that regulates mTORC1 in response to amino acids remains poorly understood. I am investigating the cellular signaling pathways that control mTORC1 activity in response to the cell surface amino acid receptor dimer T1R1/T1R3. I particularly focus on heterotrimeric G proteins and their role in transmitting signals from the receptors to mTORC1.

Punya Navaratnarajah

Punya Navaratnarajah
Postdoctoral Researcher
B.S., Chemistry, Denison University
Ph.D., Biophysics, University of North Carolina at Chapel Hill

I aim to study the mechanisms that govern the speed and amplitude with which Gαq and PLC-β3 respond to receptor stimulation by one or more agonists. Towards this end, I am currently working to establish a FRET assay to monitor Gq/PLC-β3 binding.

Nagesh Peddada

Nagesh Peddada
Postdoctoral Researcher
M.Sc. Biotechnology, Madurai Kamraj University, India
Ph.D., Structural Biology, Institute of Microbial Technology at Chandigarh, India

G protein signaling is central to G-protein-coupled receptor mediated cellular functions and is highly dynamic. Although the basic events involved in G protein signaling are well known, their quantitative regulation is poorly understood, and hard to study. My aim is to understand the quantitative mechanism of Gαq activation/deactivation in the GTPase cycle in the context of m1 Muscarinic acetylcholine receptor stimulation by agonist and/or antagonist. Further, I aim to elucidate the mechanism of how GAPs (GTPase Activating Proteins), importantly PLC-β, and receptor coordinate each otherís activity at steady state to maintain signal output under physiological conditions.


Ganesh Kadamur
Graduate Student
B.Tech., Biotechnology, Indian Institute of Technology Madras, India

I am interested in understanding the mechanisms of PLC-β regulation by Gβγ. I am using mutational analysis combined with biochemical assays and binding studies to probe Gβγ interactions with PLC-β and Gαq. Outside lab,the I love to travel, am a keen long distance runner and pursue photography as a hobby.

Alexandra Muniz

Alexandra Muniz
Research Assistant
M.S., Biology, West Texas A&M University

Elisha White

Lab Alumni >>

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