Laboratory of Elliott M. Ross

Selected Recent Publications

Biddlecome, G.H., Berstein,G., and Ross, E.M. (1996) Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor: Steady-State Balance of Receptor-Mediated Activation and GAP-Promoted Deactivation. J. Biol. Chem., 271:7999-8007. PDF

Paulssen, R.H., Woodson, J., Liu, Z., and Ross, E.M. (1996) Carboxyl-Terminal Fragments of Phospholipase C-β1 with Intrinsic Gq GTPase-Activating Protein (GAP) Activity. J. Biol. Chem., 271:26622-26629. PDF

Tu, Y., Wang, J., and Ross, E.M. (1997) Inhibition of Brain Gz GAP and Other RGS Proteins by Palmitoylation of Protein α Subunits. Science, 278:1132-1135. PDF

Wang, J., Ducret, A., Tu, Y., Kozasa, T, Aebersold, R., and Ross, E.M. (1998) RGSZ1, a Gz -Selective RGS Protein in Brain: Structure, Membrane Association, Regulation by Gz Phosphorylation, and Relationship to a Gz GTPase-Activating Protein Subfamily. J. Biol. Chem., 273:26014-26025. PDF

Mukhopadhyay, S., and Ross, E.M. (1999) Rapid GTP binding and hydrolysis by Gq promoted by receptor and GTPase-activating proteins. Proc. Natl. Acad. Sci. USA, 96:9539-9544. PDF

Tu, Y., Popov, S., Slaughter, C. and Ross, E.M. (1999) Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. J. Biol. Chem. 274:38260-38267. PDF

Ross, E.M., and Wilkie, T.M. (2000) GTPase-activating proteins (GAPs) for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem., 69:795-827. PDF

Tu, Y., Woodson, J., and Ross, E.M. (2001) Binding of RGS proteins to phospholipid bilayers: contribution of location and/or orientation to GAP activity. J. Biol. Chem., 276:20160-20166. PDF

Ilkaeva, O., Kinch, L.N., Paulssen, R.H., and Ross, E.M. (2002) Mutations of the carboxyl terminal domain of phospholipase C-b1 delineate the dimer interface and a potential Gαq interaction site. J. Biol. Chem., 277:4294-4300. PDF

Tu, Y., Nayak, S.K., Woodson, J., and Ross, E.M. (2003) Phosphorylation-regulated inhibition of the Gz GTPase-activating protein activity of RGS proteins by synapsin I. J. Biol. Chem. 278:52273-52281 (2003). PDF

Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., and Sprang, S.R. (2004) Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein a subunit. Proc. Natl. Acad. Sci. 101:7560-7565. PDF

Tang, W., Tu,Y., Nayak, S.K., Woodson J., Jehl, M. and Ross, E.M. (2006) Gβγ Inhibits Gα GTPase-activating Proteins (GAPs) by Inhibition of Gα-GTP Binding during Stimulation by Receptor. J. Biol Chem. 281:4746-4753. PDF

Ross, E.M., Mateu, D., Gomes, A.V., Arana, C., Tran, T., and Litosch, I. (2006) Structural determinants for phosphatidic acid regulation of phospholipase C-β1 J. Biol. Chem. 281:33087-33094. PDF

Jiang, L.I., Collins, J., Davis , R., Lin, K.-M., DeCamp, D., Roach, T., Hsueh, R.C., Ross, E.M., Taussig, R., Fraser, I. , and Sternweis, P.C. (2007) A sphingosine-1-phosphate/G13 pathway enhances cAMP production in murine macrophages. J. Biol. Chem. 282:10576-10584. PDF

Turcotte, M., Tang, W., and Ross, E.M. (2008) Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAPs. PLoS Comput. Biol. 4:e10000148. PDF

Ross, E.M. (2008) Coordinating speed and amplitude in G protein signaling. Curr. Biol. 18:R777-R783. PDF

Philip, F.,  Kadamur, G., González Silos, R.,  Woodson, J.  and  Ross, E.M. (2010)  Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector. Curr. Biol., 20:1327-1335. PDF

Ross, E.M., and Cobb, M.H. (2010)  Principles of Cell Signaling (Chapter 18), in Cells, L. Cassimeris, V. R. Lingappa,   G. Plopper, eds.,  Jones and Bartlett, Sudbury, MA. PDF

Rebres, R.A., Roach, T.I.A., Fraser, I.D.C., Philip, F., Moon, C., Lin, K.-M., Liu, J., Santat, L., Cheadle, L., Ross, E.M., Sternweis, P.C., Simon, M.I. and Seaman, W.E. (2011) Synergistic Ca2+ responses by Gαi- and Gαq-coupled GPCRs require a single PLC-β isoform that is sensitive to both Gβγ and Gαq. J. Biol. Chem. 286: 942-951. PDF

Ross, E.M. (2011) Gαq and Phospholipase C-β: Turn On, Turn Off, and Do It Fast. Science Signaling, 4(159):pe5 (1-3). PDF

An, S.W., Cha, S.K., Yoon, J., Chang, S., Ross, E.M. and Huang, C.L. (2011) WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling. Curr. Biol., 21:1979-1987 PDF

Chang. S., Ross, E.M. (2012) Activation biosensor for G protein-coupled receptors: a FRET-based m1 muscarinic activation sensor that regulates Gq. PLoS One, 7 (2012), p. e45651 PDF

Kadamur, G., Ross, E.M. (2013) Mammalian Phospholipase C. Annu. Rev. Physiol., 75:127-54 PDF


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