We are interested in gaining insights into the processes that underlie tumor initiation, progression and maintenance. To achieve these goals, we utilize a broad array of technologies that include cellular and molecular biology techniques mouse genetics and novel targeted drugs. We focus our interests on the promyelocytic leukemia tumor suppressor and oncogenic K-RAS. These genes control processes that are key in oncogenesis. We expect that their study will reveal the critical molecular pathways that drive tumor formation and maintenance revealing novel targets that can be exploited in cancer therapy.

Contacts:

Pier Paolo Scaglioni M.D.
UT Southwestern Medical Center
Hematology/Oncology
Simmons Cancer Center
6001 Forest Park
ND3.120A
Dallas, TX 75390-8534
Office Tel: 214/645-6449
Lab Tel: 214/645-6445
FAX: 214-645-5915

Mrs. Richonda Hunte, Administrative Associate
Tel: 214-645-5910 FAX: 214-645-5915
E-mail: Richonda.hunte@utsouthwestern.edu