Selected Publications 2012/2013
Ye, R. and P. E. Scherer. 2013. Adiponectin: Driver or Passenger on the Road to Insulin Sensitivity?
Mol. Metabolism, in press
http://www.molmetab.com/article/S2212-8778%2813%2900028-8/fulltext
Holland, W.L., Adams, A.C., Brozinick, J.T., Bui, H.H., Miyauchi, Y., Kusminski, C.M., Bauer, S.M., Wade, M., Singhal, E., Cheng, C.C., Volk, K., Kuo, M.-S., Gordillo, R., Kharitonenkov, A. and P. E. Scherer. 2013.
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice.
Cell Metabolism, in press
http://www.ncbi.nlm.nih.gov/pubmed/23663742
Park, J, Morley, T.S. and P.E. Scherer. 2013.
Inhibition of Endotrophin, a Cleavage Product of Collagen VI, Confers Cisplatin Sensitivity to Tumors
EMBO Mol Med., in press
http://www.ncbi.nlm.nih.gov/pubmed/23629957
Lopez, X., Goldfine, A. B., Holland, W.L., Gordillo, R. and P.E. Scherer. 2013.
Plasma Ceramides are Elevated in Female Children and Adolescents with Type 2 Diabetes.
Journal of Pediatric Endocrinology and Metabolism (JPEM) in press
http://www.ncbi.nlm.nih.gov/pubmed/23612696
Sun, K., Halberg, N., Khan, M., Magalang, U.J. and P. E. Scherer. 2012.
Selective Inhibition of HIF1α Ameliorates Adipose Tissue Dysfunction.
Mol Cell Biol., 33(5):904-17
http://www.ncbi.nlm.nih.gov/pubmed/23249949
Deng, Y., Wang, Z.V., Tao, C., Gao, N., Holland, W.L., Ferdous, A., Repa, J.J., Liang, G., Ye, J., Lehrman, M.A., Hill, J.A., Horton, J.D. and P. E. Scherer. 2013.
The Xbp1s-GalE axis links ER stress to postprandial metabolism.
J. Clin. Invest., 123(1):455-68
http://www.jci.org/articles/view/62819
Park, J., Sarode, V.R., Euhus, D.M., Kittler, R. and P. E. Scherer. 2012.
Neuregulin 1-HER Axis as a Key Mediator of Hyperglycemic Memory Effects in Breast Cancer.
Proc Natl Acad Sci U S A, 109(51):21058-63
http://www.ncbi.nlm.nih.gov/pubmed/23213231
Rutkowski, J.M., Wang, Z.V., Park, A.S.D., Zhang, J., Zhang, D., Hu, M.C., Moe, O.W., Susztak, K. and P. E. Scherer. 2012.
Adiponectin levels modulate functional recovery in a novel model of podocyte ablation.
J Am Soc Nephrol., 24(2):268-82
http://www.ncbi.nlm.nih.gov/pubmed/23334396
Park, J.Y. and P.E. Scherer. 2012.
The Adipocyte-Derived Factor Endotrophin Links Obesity with Malignant Tumor Progression.
J. Clin. Invest., 122(11):4243-56
http://www.ncbi.nlm.nih.gov/pubmed/23041627
Kusminski, C.M., Holland, W.L., Sun, K, Park, J.Y, Spurgin, S.B., Lin, Y., Askew, G.R., Judith A. Simcox, J.A., McClain, D.A., Li, C. and P E. Scherer. 2012.
MitoNEET, a key regulator of mitochondrial function and lipid homeostasis.
Nat Med, 18(10):1539-49
http://www.ncbi.nlm.nih.gov/pubmed/22961109
Wernstedt Asterholm, I., Mundy, D.I., Weng, J., , Anderson, R.G.W and P.E. Scherer. 2012.
Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1.
Cell Metabolism, 15 (2), 171-185
http://www.ncbi.nlm.nih.gov/pubmed/22326219
Wernstedt Asterholm, I., McDonald, J., Blanchard, P.G., Sinha, M., Xiao, Q., Mistry, J., Rutkowski, J.M., Dehaies, Y., Brekken, R.A and P. E. Scherer. 2012.
Lack of ”Immunological Fitness” During Fasting in Metabolically Challenged Animals.
J. Lipid Research, 53(7):1254-67
http://www.ncbi.nlm.nih.gov/pubmed/22504909
Sun, K., Wernstedt Asterholm, I., Kusminski, C.M., Bueno, A.C., Wang, Z. V., Pollard, J.W., Brekken, R.A. and P. E. Scherer. 2012.
Dichotomous Effects of VEGF-A on Adipose Tissue Dysfunction.
Proc Natl Acad Sci U S A, 109(15):5874-9
http://www.ncbi.nlm.nih.gov/pubmed/22451920
Sun, K., and Scherer, P.E., 2013.
Metabolic Roles of Adiponectin.
In: Lennarz, W.J. and Lane, M.D. (eds.)
The Encyclopedia of Biological Chemistry, Vol. 3, pp. 72-75. Waltham, MA: Academic Press.
Wernstedt Asterholm, I. and P. E. Scherer. 2012.
Metabolic jet lag when the fat clock is out of sync.
Nat. Med, 18(12):1738-40
http://www.ncbi.nlm.nih.gov/pubmed/23223058
Park J. and P.E. Scherer. 2013.
Endotrophin in the tumor stroma: a new therapeutic target for breast cancer?
Expert Rev Anticancer Ther., 13(2):111-3
http://www.ncbi.nlm.nih.gov/pubmed/23406549
Turer, A.T., Hill, J.A., Elmquist, J.K. and P.E. Scherer. 2012.
Adipose Tissue Biology and Cardiomyopathy- Translational Implications.
Circ. Res., 111:1565-1577
http://www.ncbi.nlm.nih.gov/pubmed/23223931
Park J. and P.E. Scherer. 2012.
Endotrophin – Linking Obesity with Aggressive Tumor Growth
Oncotarget, 3(12):1487-8
http://www.ncbi.nlm.nih.gov/pubmed/23328277
Hefetz-Sela, S. and P.E. Scherer. 2012.
Adipocytes: Impact on Tumor Growth and Potential Sites for Therapeutic Intervention.
Pharmacol Ther., 138: 197–210
http://www.ncbi.nlm.nih.gov/pubmed/23353703
Sun, K. and P.E. Scherer. 2012.
The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis.
Cell Res., 22(10):1416-8
http://www.ncbi.nlm.nih.gov/pubmed/22710798
Elmquist JK and P.E. Scherer. 2012.
The cover. Neuroendocrine and endocrine pathways of obesity.
JAMA, 308(11):1070-1
http://www.ncbi.nlm.nih.gov/pubmed/22990243
Kusminski, C.M. and P. E. Scherer. 2012.
Mitochondrial Dysfunction in White Adipose Tissue.
Trends in Endocrinology & Metabolism, 23(9):435-43
http://www.ncbi.nlm.nih.gov/pubmed/22784416
Turer, A. and P.E. Scherer. 2012.
Adiponectin: Mechanistic Insights and Clinical Implications.
Diabetologia, 55(9):2319-26
http://www.ncbi.nlm.nih.gov/pubmed/22688349
Turer, A.T., Browning , J.D., Ayers, C.R., Das , S.R., Khera , A., Vega , G.L., Grundy, S.M. and P. E. Scherer. 2012.
Adiponectin as an Independent Predictor of the Presence and Degree of Hepatic Steatosis in the Dallas Heart Study.
J Clin Endocrinol Metab., 97(6):E982-6.
http://www.ncbi.nlm.nih.gov/pubmed/22438228
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He, C., Bassik, M.C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., Korsmeyer, S., Packer, M., May, H.I., Hill, J.A., Virgin, H.W., Gilpin, C., Xiao, G., Bassel-Duby, R., Scherer, P.E. and B. Levine. 2012.
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
Nature. 18;481(7382):511-5
http://www.ncbi.nlm.nih.gov/pubmed/22258505
Durand, J.L., Nawrocki, A.R., Scherer, P.E. and L.A. Jelicks. 2012.
Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase.
Journal of Cellular Biochemistry, 113(10):3276-87
http://www.ncbi.nlm.nih.gov/pubmed/22644792
Suk, H.Y., Zhou, C., Yang, T.T., Zhu, H., Yu, R.Y., Olabisi, O., Yang, X., Brancho, D., Kim, J.Y., Scherer, P.E., Frank, P.G., Lisanti, M.P., Calvert, J.W., Lefer, D.J., Molkentin, J.D., Ghigo, A., Hirsch, E., Jin, J. and C.W. Chow. 2012.
Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Crosstalks with Phosphodiesterases.
J Biol Chem., in press
http://www.ncbi.nlm.nih.gov/pubmed/23258544
Lopez, X., Goldfine, A. B., Holland, W.L., Gordillo, R. and P.E. Scherer. 2013.
Plasma Ceramides are Elevated in Female Children and Adolescents with Type 2 Diabetes
Journal of Pediatric Endocrinology and Metabolism (JPEM) in press
Drager, L.F., Yao, Q., Hernandez, K.L., Shin, M.K., Bevans-Fonti, S., Gay, J., Sussan, T.E., Jun, J.C., Myers, A.C., Olivecrona, G., Schwartz, A.R., Halberg, N., Scherer, P.E., Semenza, G.L., Powell, D.R. and V.Y. Polotsky. 2013.
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
Am J Respir Crit Care Med., in press
http://www.ncbi.nlm.nih.gov/pubmed/23328524
Liu, J., Guo, M., Zhang, D., Cheng, S.-Y., Liu, M., Ding, J., Scherer, P.E., Liu, F. and X.Y. Lu. 2012. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.
Proc Natl Acad Sci U S A, 109(30):12248-53
http://www.ncbi.nlm.nih.gov/pubmed/22778410
Liu, M., Xiang, R., Wilk, S. A., Zhang, N., Azarnoush, K., Sloane, L.B., Zhou, L., Chen, H., Xiang, G., Walter, C., Austad, S. N., Musi, N., DeFronzo, R., Asmis, R., Scherer, P.E., Dong, L.Q. and Feng Liu. 2012.
Fat-specific DsbA-L overexpression promotes adiponectin multimerization and prevents mice from diet-induced obesity and insulin resistance.
Diabetes, 109(30):12248-53
http://www.ncbi.nlm.nih.gov/pubmed/22807031
Fraterrigo, G., Fabbrini, E., Mittendorfer, B., O'Rahilly, S., Scherer, P.E., Patterson, B.W. and S. Klein. 2012.
Relationship between Changes in Plasma Adiponectin Concentration and Insulin Sensitivity after Niacin Therapy.
Cardiorenal Med.;2(3):211-217
http://www.ncbi.nlm.nih.gov/pubmed/22969777
Murano, I., Rutkowski, J.M., Wang, Q.A., Cho, Y.R., Scherer, P.E. and S. Cinti. 2012.
Time course of histomorphological changes in adipose tissue upon acute lipoatrophy.
Nutr Metab Cardiovasc Dis., in press
http://www.ncbi.nlm.nih.gov/pubmed/22682975
Shetty, S., Ramos-Roman, M.A., Cho, Y.R., Brown, J., Plutzky, J., Muise, E.S., Horton, J.D., Scherer P.E. and E.J. Parks. 2012.
Enhanced Fatty Acid Flux Triggered by Adiponectin Overexpression.
Endocrinology; 153(1):113–122
http://www.ncbi.nlm.nih.gov/pubmed/22045665
Keuper, M, Wernstedt Asterholm, I., Scherer, P.E. Westhoff, M.A., Möller, P., Debatin, K.M., Strauss, G., Wabitsch, M. and P. Fischer-Posovszky. 2012.
TRAIL (TNF Related Apoptosis Inducing Ligand) Regulates Adipocyte Metabolism by Caspase-mediated Cleavage of PPARg.
Cell Death and Disease, 4, e474
http://www.ncbi.nlm.nih.gov/pubmed/23348588
Khan, U.I., Wang, D., Sowers, M.R., Mancuso, P., Everson-Rose, S.A., Scherer, P.E. and R.P. Wildman. 2012.
Race-ethnic differences in adipokine levels: the Study of Women's Health Across the Nation (SWAN).
Metabolism, 61(9):1261-9
http://www.ncbi.nlm.nih.gov/pubmed/22444780
Ho G.Y., Wang, T., Gunter, M.J., Strickler, H.D., Cushman, M., Kaplan, R.C., Wassertheil-Smoller S., Xue, X., Rajpathak, S.N., Chlebowski, R.T., Vitolins, M.Z., Scherer, P.E. and T.E. Rohan. 2012.
Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women.
Cancer Res., 72(12):3029-3037
http://www.ncbi.nlm.nih.gov/pubmed/22511581
Wildman, R.P., Wang, D., Fernandez, I., Mancuso, P., Santoro, N., Scherer, P.E. and M.R. Sowers. 2012. Associations of Testosterone and Sex Hormone Binding Globulin with Adipose Tissue Hormones in Midlife Women.
Obesity, in press
http://www.ncbi.nlm.nih.gov/pubmed/22543554
Nagajyothi, F., Kuliawat, R., Kusminski, C.M., Machado, F.S., Desruisseaux, M.S., Zhao, D., Schwartz, G.J., Huang, H., Albanese, C. A., Lisanti, M.P., Singh, R. Feng, L., Weiss, L.M., Factor, S.M., Pessin J., Scherer, P.E. and H. B. Tanowitz. 2012.
Alterations in glucose homeostasis in a murine model of Chagas disease.
Am J Path; 178(6):2690-9
http://www.ncbi.nlm.nih.gov/pubmed/23321322
Nagajyothi, F., Machado, F.S., Burleigh, B.A., Jelicks, L.A., Scherer, P.E., Mukherjee, S., Lisanti, M.P., Weiss, L.M., Garg, N.J. and H.B. Tanowitz. 2012.
Mechanisms of Trypanosoma cruzi persistence in Chagas disease.
Cell Microbiol., 14(5):634-43
http://www.ncbi.nlm.nih.gov/pubmed/22309180
Nagajyothi, F., Desruisseaux, M.S., Machado, F.S., Upadhya, R., Zhao, D., Schwartz, G.J., Teixeira, M.M., Albanese, C., Lisanti, M.P., Chua, S.C. Jr, Weiss, L.M., Scherer, P.E. and H.B. Tanowitz. 2012.
Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain).
J Infect Dis.;205(5):830-40
http://www.ncbi.nlm.nih.gov/pubmed/22293433