Recent Selected Articles

Optogenetic stimulation of accumbens shell or shell projections to lateral hypothalamus produce differential effects on the motivation for cocaine.  Larson E.B., Wissman A.M., Loriaux A.L., Kourrich S., Self D.W. Journal of Neuroscience 35(8):3537-43 (2015). PubMed PMID: 25716852.

Over-expression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats.  Larson, E.B., Graham, D.L., Arzaga, R.R., Buzin, N., Webb, J., Green, T., Bass, C.E., Neve, R.L., Terwilliger, E.F., Nestler, E.J. and Self, D.W. Journal of Neuroscience 31:16447-16457 (2011). PMC3229171.

Reinforcement-related up-regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine.  Choi, K. H., Edwards, S. Graham, D.L., Larson, E.B., Whisler, K.N., Simmons, D., Friedman, A.K., Walsh, J.J., Rahman, Z., Monteggia, L.M., Eisch, A.J., Neve, R.L., Nestler, E.J., Han, M-H. and Self, D.W. Journal of Neuroscience 31:7927-7937 (2011). PMID: 21613507

Emergence of context-associated GluR1 and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Edwards, S., Bachtell, R.K., Guzman, D., Whisler, K.N. and Self, D.W. Addiction Biology 16:450-457 (2011). NIHMS ID: 283414

Integrating behavioral and molecular approaches in mouse self-administration studies. Graham, D.L. and Self, D.W.  Frontiers in the Neurobiology of Addiction, Kuhn, C. M. and Koob, G.F., eds., CRC Press, 163-192 (2010). PMID: 21656975

Striatal regulation of FosB and ΔFosB and cFos during cocaine self-administration and withdrawal. Larson, E.B., Akkentli F., Edwards, S., Graham, D.L., Simmons, D.L., Alibhai, I.M., Nestler, E.J. and Self, D.W.   Journal of Neurochemistry 115:112-122 (2010). PMCID: 2939959

Dopamine receptor subtypes in reward and relapse. Self, D.W.  The Dopamine Receptors: Second Edition, Neve, K. ed., Humana Press, 479-524 (2010).

Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior. Simmons, D., and Self, D. W. Neuropsychopharmacology 34:1946-1957 (2009).

Tropomyosin-related kinase B in the mesolimbic dopmine system: region-specific effects on cocaine reward.Graham, D. L., Vaishnav, K., Larson, E. B., Graham, A., Edwards, S., Bachtell, R. K., Simmons, D., Gent, L. M., Berton, O., Bolanos, C. A., DiLeone, R. J., Parada, L. F., Nestler, E. J., and Self, D. W. Biol. Psychiatry 65:696-701 (2009).

Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. Bachtell, R.K., Choi,K-H., Monteggia, L.M., Neve, R. L. and Self, D.W. Eur. J. Neurosci. 27:2229-2240 (2008).

Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Graham, D.L., Edwards, S., Bachtell, R.K., DiLeone, R.J, Rios, M. and Self, D.W. Nature Neuroscience 10:1029-1037 (2007).

Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. Edwards, S., Whisler, K.N., Fuller, D.C., Orsulak, P.J. and Self, D.W. Neuropsychopharmacology 35:354-366 (2007).

Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Edwards, S., Graham, D.L., Bachtell, R.K. and Self, D.W. European Journal of Neuroscience 25:2201-2213 (2007).

Monogamy: Dopamine ties the knot. Edwards, S. and Self, D.W. Nature Neuroscience 9:7-8 (2006).

Molecular and genetic approaches for behavioral analysis of protein function. Self, D.W. Biological Psychiatry 57:1479-1484 (2005).

Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration. Self, D.W. Choi, K-H., Simmons, D., Walker, J.R. and Smagula, C.S. Learning and Memory 11:648-657 (2004).

Regulation of drug-taking and –seeking behaviors by neuroadaptations in the mesolimbic dopamine system. Self, D.W. Neuropharmacology 47S1:242-255 (2004).

Extinction-induced up-regulation in AMPA receptors reduces cocaine-seeking behavior. Sutton, M.A., Schmidt, E.F., Choi, K-H., Schad, C.A., Whisler, K., Simmons, D., Karanian, D.A., Monteggia, L.M., Neve, R.L. and Self, D.W. Nature 421:70-75 (2003).