prostate histology

Our laboratory investigates the mechanisms responsible for transforming normal cells into cancer cells. We currently focus on the connection between oncogenic receptor tyrosine kinases and Huntingtin Interacting Protein 1 (HIP1), a protein involved in clathrin mediated intracellular protein trafficking. We also use mouse models to study the in vivo roles of tyrosine kinase oncogenes created by chromosomal translocations (HIP1/PDGFβR and BCR/ABL) in leukemia initiation, maintenance and sensitivity to chemotherapy.