Selected Publications

Ames HM, Bichakjian CK, Liu GY, Oravecz-Wilson KI, Fullen DR, Verhaegen M, Johnson TM, Dlugosz, AA and Ross TS. Huntingtin Interacting Protein 1: A Merkel Cell Carcinoma Marker That Interacts with c-Kit. J. Invest. Derm.131(10):2113-20, 2011.

Oravecz-Wilson KI, Philips ST, Yilmaz OH, Li L, Crawford BD, Gauvin AM, Lucas PC, Sitwala K, Downing JR, Morrison SJ and Ross TS. Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative Disorder. Cancer Cell 16(2):137-48, 2009.

Graves CW, Philips ST, Bradley SV, Oravecz-Wilson KI, Li L, Gauvin A and Ross TS. Use of a Cryptic Slice Site for the Expression of Huntingtin Interacting Protein 1 in Select Normal and Neoplastic Tissues. Cancer Res. 68(4):1064-73, 2008.

Bradley SV, Smith MR, Li L, Hyun TS, Lucas PC, Joshi I, Jin F, Antonuk D and Ross TS. Aberrant Huntingtin Interacting Protein 1 in Lymphoid Malignancies. Cancer Res. 67(18):8923-31, 2007.

Bradley SV*, Hyun TS*, Oravecz-Wilson KI, Li L, Waldorff E, Ermilov A, Goldstein S, Zhang CX, Drubin DG, Varela K, Parlow A, Dlugosz AA and Ross TS. Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum Mol Genet. 16(11):1279-92, 2007. (*joint First Authors)

Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS and Ross TS. Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor. Cancer Res. 67(8):3609-15, 2007.

Bradley SV, Oravecz-Wilson KI, Gougeard G, Mizukami I, Li L, Munaco AJ, Sreekumar A, Chinnaiyan AM, Corradetti MN, Sanda MG, Ross TS. Serum Antibodies to Huntingtin Interacting Protein-1: A New Blood Test for Prostate Cancer. Cancer Res. 65(10):4126-4133, 2005.

Hyun TS, Oravecz-Wilson KI, Li L, Munaco AJ, Provot MM, Mizukami IF and Ross TS. Hip1-related Mutant Mice Grow and Develop Normally but Have Accelerated Spinal Abnormalities and Dwarfism in the Absence of HIP1. Mol. Cell. Biol. 24(10):4329-40, 2004.

Hyun TS and Ross TS. HIP1: trafficking roles and regulation of tumorigenesis. Trends in Molecular Medicine 10(4):194-9, 2004.

Oravecz-Wilson, K. I., M. J. Kiel, D. S. Rao, D. Saint-dic, L. Li, P. D. Kumar, M. M. Provot, S. V. Bradley, K. D. Hankenson, V. N. Reddy, A. P. Lieberman, S. J. Morrison, and T. S. Ross. Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum. Mol. Gen. 13(8):851-67, 2004.

Hyun TS, Rao DS, Saint-Dic D, Michael E, Kumar PD, Bradley SV, Mizukami IF, Oravecz- Wilson KI, and Ross TS. HIP1 and HIP1r Stabilize Receptor Tyrosine Kinases and Bind 3-Phoshoinositides via Epsin N-terminal Homology Domains. J. Biol. Chem. 279(14):14294-306, 2004.

Bradley SV*, Rao DS*, Kumar PD, Hyun TS, Saint-dic D, Oravecz-Wilson KI, Kleer CG and Ross TS. Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer Cell 3:471-482, 2003. (*These two authors contributed equally to this work)

Rao D S, Hyun T S, Mizukami I, Rubin M, Lucas P, Ross TS. Huntingtin-interacting protein 1 is overexpressed in cancer cells and its ENTH domain is critical for cellular survival. J. Clin. Invest. 110(3):351-360, 2002.

Mishra SK, Agostinelli NR, Brett TJ, Mizukami I, Ross TS, Traub LM. Clathrin and AP-2 binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. J. Biol. Chem. 276:46320-326, 2001.

Rao D., Chang JC, Kumar P, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Huntingtin Interacting Protein 1 is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors. Mol. Cell. Biol. 21:7796-7806, 2001.

Saint-Dic J, Chang SC, Taylor GS, Provot MM, Ross TS. Regulation of the SH2-containing inositol 5-phoshatase SHIP1 in HIP1/PDGFbetaR transformed cells. J. Biol. Chem. 276:21192-198, 2001.

Ross TS, Gilliland DG. Transforming Properties of the Huntingtin Interacting Protein 1/ Platelet-derived Growth Factor β Receptor Fusion Protein J. Biol. Chem. 274:22328-22336, 1999.

Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntingtin Interacting Protein 1 to PDGFβR in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood 91:4419-4426, 1998.