Publications

2007 - present

  • Cai L, McCormick MA, Kennedy BK, Tu BP. Integration of Multiple Nutrient Cues and Regulation of Lifespan by Ribosomal Transcription Factor Ifh1. Cell Rep. 2013;4:1063-71.
  • Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP. Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell. 2013;154:416-29.
  • Sutter BM, Wu X, Laxman S, Tu BP. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell. 2013;154:403-15.
  • Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Proc Natl Acad Sci USA. 2013;110:9728-33.
  • Xiao Y, Nguyen S, Kim SH, Volkov OA, Tu BP, Phillips MA. Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme. Mol Microbiol. 2013;88:846-61.
  • Shi L, Tu BP. Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae. Proc Natl Acad Sci USA. 2013;110:7318-23.
  • Kriel A, Bittner AN, Kim SH, Liu K, Tehranchi AK, Zou WY, Rendon S, Chen R, Tu BP, Wang JD. Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance. Mol Cell. 2012;48:231-41.
  • Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Sonyang Z. Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol Cell. 2012;47:839-50.
  • Kaochar S, Tu BP. Gatekeepers of chromatin: small metabolites elicit big changes in gene expression. Trends Biochem Sci. 2012;37:477-83.
  • Cai L, Tu BP. Driving the cell cycle through metabolism. Annu Rev Cell Dev Biol. 2012;28:59-87.
  • Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Cai L, Good L, Tu BP, Hatanpaa K, Mickey BE, Mates JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metabolism. 2012;15:827-37.
  • Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM. Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol. 2012;196:315-26.
  • Laxman S, Tu BP. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. PLoS One. 2011;6:e26081.
  • Wu X, Tu BP. Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Mol Biol Cell. 2011;22:4124-33.
  • Cai L, Tu BP. On acetyl-CoA as a gauge of cellular metabolic state. Cold Spring Harb Symp Quant Biol. 2011;76:195-202.
  • Cai L, Tu BP. Acetyl-CoA drives the transcriptional growth program in yeast. Cell Cycle. 2011;10:3045-6.
  • Cai L, Sutter BM, Li B, Tu BP. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell. 2011; 42:426-37.
  • Humston EM, Dombek KM, Tu BP, Young ET, Synovec RE. Toward a global analysis of metabolites in regulatory mutants of yeast. Anal Bioanal Chem. 2011;401:2387-402.
  • Laxman S, Tu BP. Systems approaches for the study of metabolic cycles in yeast. Curr Opin Genet Dev. 2010; 20:599-604
  • Laxman S, Tu BP. Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters. PLoS One. 2010; 5:e12595.
  • Shi L, Sutter BM, Ye X, Tu BP. Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth. Mol Biol Cell. 2010; 21:1982-90.
  • Tu BP. Ultradian metabolic cycles in yeast. Methods Enzymol. 2010; 470:857-66.
  • Tu BP*, McKnight SL*. Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle. Proc Natl Acad Sci USA. 2009; 106:14293-6.
  • Mohler RE, Tu BP, Dombek KM, Hoggard JC, Young ET, Synovec RE. Identification and evaluation of cycling yeast metabolites in GC x GC-TOFMS data. J Chromatogr A. 2008; 1186:401-411.
  • pre 2007

  • Tu BP, McKnight SL. The yeast metabolic cycle: Insights into the life of a eukaryotic cell. Cold Spring Harb Symp Quant Biol. 2007; 72:339-343.   [source]
  • Tu BP*, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL*. Cyclic changes in metabolic state during the life of a yeast cell; Proc Natl Acad Sci USA. 2007; 104:16886-16891.   [source]
  • Rowicka M, Kudlicki A, Tu BP, Otwinowski Z. High-resolution timing of cell cycle-regulated gene expression. Proc Natl Acad Sci USA. 2007; 104:16892-16897.   [source]
  • Chen Z, Odstrcil EA, Tu BP, McKnight SL. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science. 2007; 316:1916-1919.
  • Tu BP, McKnight SL. Metabolic cycles as an underlying basis of biological oscillations. Nat Rev Mol Cell Biol. 2006; 7:696-701.   [source]
  • Tu BP, Kudlicki A, Rowicka M, McKnight SL. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science. 2005; 310:1152-1158.   [source]
  • Tu BP, Weissman JS. Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol. 2004; 164:341-346.   [source]
  • Tu BP, Weissman JS. The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell. 2002; 10:983-994.   [source]
  • Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS. Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science. 2000; 290:1571-1574   [source]
  • Tu BP, Wang JC. Protein footprinting at cysteines: probing ATP-modulated contacts in cysteine-substitution mutants of yeast DNA topoisomerase II. Proc Natl Acad Sci USA. 1999; 96:4862-4867.   [source]
  • Tse B, Blazey CM, Tu B, Balkovec J. Determination of the absolute stereochemistry of (-)-galbonolide A. J Org Chem. 1997; 62:3236-3241.

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