Journal Cover Images

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Publications

Jin Z, Wei W, Yang M, Du Y and Wan Y (2014) Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Tipping the Balance of Macrophage-Osteoclast Polarization. Cell Metabolism, in press.

Krzeszinski JY, Wei W, Huynh HD, Jin Z, Wang X, Chang TC, Xie XJ, He L, Mangala LS, Lopez-Berestein G, Sood AK, Mendell JT and Wan Y (2014) miR-34a Blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2. Nature, epub. PDF; UTSW News & Highlight in Nature Review Rheumatology

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M and Wan Y (2014) Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metabolism, 19(6):927-40. PDF; UTSW News & NPR Radio

Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinun S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y* and Rosen CJ* (2014) FGF-21 and Skeletal Remodeling During and After Lactation in C57BL6 Mice. Endocrinology, epub ahead of print. (*corresponding author). PDF

Wan Y (2013) iBAT on Bone. Endocrinology, 154(8):2579-2580. PDF

Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y and Elmquist JK (2013) Neuronal and Nonneuronal Cholinergic Structures in the Mouse Gastrointestinal Tract and Spleen. J Comp Neurol, 521(16):3741-3767. PDF

Jin Z, Wei W, Dechow PC and Wan Y (2013) HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered beta-Catenin Switch. Molecular Endocrinology, 27(2): 325-335. Editor's Choice. PDF

Wan Y (2012) Bone Marrow Mesenchymal Stem Cells: Fat On and Blast Off by FGF21. The International Journal of Biochemistry and Cell Biology, 45(3):546-549. PDF

Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y Yu RT, Evans RM, Kliewer SA and Mangelsdorf DJ (2012) The Starvation Hormone, Fibroblast Growth Factor-21, Extends Lifespan in Mice. eLife, 1:e00065. PDF

Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A and Wan Y (2012) Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates. Nature Communications, 3:1008. PDF; Nature Communications News Release

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A and Wan Y (2012) Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity. Genes & Development 26(12):1306-11. PDF; UTSW Feature

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA and Wan Y (2012) Fibroblast Growth Factor 21 Promotes Bone Loss by Potentiating the Effects of PPARγ. Proc Natl Acad Sci U S A.109(8):3143-8. PDF; UTSW News Release

Wei W and Wan Y (2011) Thiazolidinediones on PPARγ: the Roles in Bone Remodeling. PPAR Research, 2011:867180. PDF

Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM and Wan Y (2011) Osteoclast Progenitors Reside in PPARγ-Expressing Bone Marrow Cell Population. Molecular and Cellular Biology 31(23): 4692-4705. PDF, Supplementary Information

Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM and Wan Y (2011) Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by β-Catenin. Molecular and Cellular Biology, 31(23): 4706-4719. PDF, Supplementary Information

Wan Y (2010) PPARγ in Bone Homeostasis. Trends in Endocinology and Metabolism, 21:722-728 PDF

Wei W, Wang X, Yang M, Smith LC, Dechow PC and Wan Y (2010) PGC1b Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss. Cell Metabolism 11:503-516. PDF

Wan Y* and Evans RM (2010) Rosiglitazone Activation of PPARγ Suppresses Fractalkine Signalin. Journal of Molecular Endocrinology 44:135-142. (*corresponding author). PDF

Wan Y , Chong LW and Evans RM (2007) PPARγ Regulates Osteoclastogenesis in Mice. Nature Medicine 13:1496-1503. PDF ; Commentary in Cell Metabolism

Wan Y , Saghatelian A, Chong LW, Zhang CL, Cravatt BF and Evans RM (2007) Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk. Genes & Development 21:1895-1908. PDF ; HHMI news ; Editors' Choice in Science & STKE

Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y and Chrousos GP (2003) Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. Journal of Biological Chemistry 278(28):25651-25656

Wan Y and Nordeen SN (2003) Overlapping but distinct profiles of gene expression elicited by glucocorticoids and progestins. Recent Progress in Hormone Research 58:199-226

Wan Y and Nordeen SN (2002) Identification of genes differentially regulated by glucocorticoids and progestins using a Cre/ loxP mediated retroviral promoter-trapping strategy. Journal of Molecular Endocrinology 28(3):177-92

Wan Y and Nordeen SN (2002) Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells. Molecular Endocrinology 16(6):1204-1214

Nordeen SK , Housley PR, Wan Y and Day RN (2001) Application of Green Fluorescent Protein to study of dynamic protein-protein interactions and subcellular trafficking of steroid receptors. Methods in Molecular Biology, vol.176: Steroid Receptor Methods: Protocol and Assays: 179-199

Wan Y , Coxe KK, Thackray VG, Housley PR and Nordeen SK (2001) Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Molecular Endocrinology 15(1):17-31

Schaufele F, Chang C, Liu W, Baxter JD, Nordeen SK, Wan Y , Day RN and McDonnell DP (2000) Temporally distinct, ligand-specific recruitment of nuclear receptor interacting peptides and co-factors to the estrogen receptor in the cellular environment. Molecular Endocrinology 14(12):2024-2039

Day RN, Nordeen SK and Wan Y (1999) Visualizing protein-protein interactions in the nucleus of the living cell. Molecular Endocrinology 13(4):517-526