Journal Cover Images




Huynh HD and Wan Y (2018) mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1. Communications Biology - Nature, 1:29. PDF

Du Y, Sun T, Liang X, Li Y, Jin Z, Xue H, Wan Y, and Tian J (2017) Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model. Int J Nanomedicine, 12:8337-8351. PDF

Yang D, Huynh H and Wan Y (2017) Milk lipid regulation at the maternal-offspring interface. Semin Cell Dev Biol, pii: S1084-9521(17)30390-7. PDF

Huynh HD, Wei W and Wan Y (2017) mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss. Cell Reports, 19:20142025. PDF ; UTSW Research Highlight

Xiong H, Zuo H, Yan Y, Occhialini G, Zhou K, Wan Y and Siegwart DJ (2017) High contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastasis via size controlled pH-activatable water soluble probes. Advanced Materials, epub ahead of print. PDF

Zuo H and Wan Y (2017) Nuclear Receptors in Skeletal Homeostasis. Current Topics in Developmental Biology, epub ahead of print. PDF

Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ and Wan Y (2017) Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A, 114(3):580-585. PDF

Krzeszinski JY, Schwaid AG, Cheng WY, Jin Z, Gallegos ZR, Saghatelian A and Wan Y (2017) Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. Endocrinology, 158(3):477-489. PDF; Featured Article with PaperClip video; News and Views commentary

Pena-Llopis S, Wan Y and Martinez ED (2016) Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget, 7(52):85819-85831. PDF

Cheng WY, Huynh H, Chen P, Pena-Llopis S and Wan Y (2016) Macrophage PPAR? inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone. Elife, doi: 10.7554/eLife.18501. PDF

Baier SR and Wan Y (2016) MicroRNA Exert Macro Effects on Cancer Bone Metastasis. Curr Osteoporos Rep., 14(5):163-9. PDF

Li X, Huynh H, Zuo H, Salminen M and Wan Y (2016) Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice. Endocrinology, 157(3):1021-8. PDF

Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, Saghatelian A and Wan Y (2016) Ligand Activation of ERRa by Cholesterol Mediates Statin and Bisphosphonate Effects. Cell Metabolism, 23(3):479-91. PDF & Highlight in Cell Chemical Biology

Wang X, Wei W, Krzeszinski JY, Wang Y and Wan Y (2015) A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption. Cell Metabolism, 22(5):811-24. PDF & Highlight in Nature Reviews Endocrinology

Li X, Wei W, Huynh HD, Zuo H, Wang X and Wan Y (2015) Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation. eLife, doi: 10.7554. PDF

Krzeszinski JY and Wan Y (2015) New Therapeutic Targets for Cancer Bone Metastases. Trends in Pharmacological Sciences, 36(6):360-373. PDF

Jin Z, Wei W, Huynh H and Wan Y (2015) HDAC9 Inhibits Osteoclastogenesis via Mutual Suppression of PPARgamma/RANKL Signaling. Molecular Endocrinology, 29(5):730-738. PDF

Wang X, Wei W, Zinn AR and Wan Y (2015) Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice. Endocrinology, 156(4):1408-15. PDF

Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A and Wan Y (2015) Maternal adiponectin controls milk composition to prevent neonatal inflammation. Endocrinology, 156:1504. PDF

Jin Z, Li X and Wan Y (2015) Minireview: nuclear receptor regulation of osteoclast and bone remodeling. Molecular Endocrinology, 29(2):172-86. PDF

Jin Z, Wei W, Yang M, Du Y and Wan Y (2014) Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Tipping the Balance of Macrophage-Osteoclast Polarization. Cell Metabolism, 20(3):483-498. PDF; Cell Metabolsim Cover; Preview in Immunity

Krzeszinski JY, Wei W, Huynh HD, Jin Z, Wang X, Chang TC, Xie XJ, He L, Mangala LS, Lopez-Berestein G, Sood AK, Mendell JT and Wan Y (2014) miR-34a Blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2. Nature, 512(7515):431-435. PDF; UTSW News & Highlight in Nature Review Rheumatology

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M and Wan Y (2014) Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metabolism, 19(6):927-40. PDF; UTSW News & NPR Radio & IBMS BoneKEy

Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinun S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y* and Rosen CJ* (2014) FGF-21 and Skeletal Remodeling During and After Lactation in C57BL6 Mice. Endocrinology, epub ahead of print. (*corresponding author). PDF

Wan Y (2013) iBAT on Bone. Endocrinology, 154(8):2579-2580. PDF

Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y and Elmquist JK (2013) Neuronal and Nonneuronal Cholinergic Structures in the Mouse Gastrointestinal Tract and Spleen. J Comp Neurol, 521(16):3741-3767. PDF

Jin Z, Wei W, Dechow PC and Wan Y (2013) HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered beta-Catenin Switch. Molecular Endocrinology, 27(2): 325-335. Editor's Choice. PDF

Wan Y (2012) Bone Marrow Mesenchymal Stem Cells: Fat On and Blast Off by FGF21. The International Journal of Biochemistry and Cell Biology, 45(3):546-549. PDF

Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y Yu RT, Evans RM, Kliewer SA and Mangelsdorf DJ (2012) The Starvation Hormone, Fibroblast Growth Factor-21, Extends Lifespan in Mice. eLife, 1:e00065. PDF

Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A and Wan Y (2012) Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates. Nature Communications, 3:1008. PDF; Nature Communications News Release

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A and Wan Y (2012) Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity. Genes & Development 26(12):1306-11. PDF; UTSW Feature

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA and Wan Y (2012) Fibroblast Growth Factor 21 Promotes Bone Loss by Potentiating the Effects of PPARγ. Proc Natl Acad Sci U S A.109(8):3143-8. PDF; UTSW News Release

Wei W and Wan Y (2011) Thiazolidinediones on PPARγ: the Roles in Bone Remodeling. PPAR Research, 2011:867180. PDF

Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM and Wan Y (2011) Osteoclast Progenitors Reside in PPARγ-Expressing Bone Marrow Cell Population. Molecular and Cellular Biology 31(23): 4692-4705. PDF, Supplementary Information

Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM and Wan Y (2011) Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by β-Catenin. Molecular and Cellular Biology, 31(23): 4706-4719. PDF, Supplementary Information

Wan Y (2010) PPARγ in Bone Homeostasis. Trends in Endocinology and Metabolism, 21:722-728 PDF

Wei W, Wang X, Yang M, Smith LC, Dechow PC and Wan Y (2010) PGC1b Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss. Cell Metabolism 11:503-516. PDF

Wan Y* and Evans RM (2010) Rosiglitazone Activation of PPARγ Suppresses Fractalkine Signalin. Journal of Molecular Endocrinology 44:135-142. (*corresponding author). PDF

Wan Y , Chong LW and Evans RM (2007) PPARγ Regulates Osteoclastogenesis in Mice. Nature Medicine 13:1496-1503. PDF ; Commentary in Cell Metabolism

Wan Y , Saghatelian A, Chong LW, Zhang CL, Cravatt BF and Evans RM (2007) Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk. Genes & Development 21:1895-1908. PDF ; HHMI news ; Editors' Choice in Science & STKE

Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y and Chrousos GP (2003) Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. Journal of Biological Chemistry 278(28):25651-25656

Wan Y and Nordeen SN (2003) Overlapping but distinct profiles of gene expression elicited by glucocorticoids and progestins. Recent Progress in Hormone Research 58:199-226

Wan Y and Nordeen SN (2002) Identification of genes differentially regulated by glucocorticoids and progestins using a Cre/ loxP mediated retroviral promoter-trapping strategy. Journal of Molecular Endocrinology 28(3):177-92

Wan Y and Nordeen SN (2002) Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells. Molecular Endocrinology 16(6):1204-1214

Nordeen SK , Housley PR, Wan Y and Day RN (2001) Application of Green Fluorescent Protein to study of dynamic protein-protein interactions and subcellular trafficking of steroid receptors. Methods in Molecular Biology, vol.176: Steroid Receptor Methods: Protocol and Assays: 179-199

Wan Y , Coxe KK, Thackray VG, Housley PR and Nordeen SK (2001) Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Molecular Endocrinology 15(1):17-31

Schaufele F, Chang C, Liu W, Baxter JD, Nordeen SK, Wan Y , Day RN and McDonnell DP (2000) Temporally distinct, ligand-specific recruitment of nuclear receptor interacting peptides and co-factors to the estrogen receptor in the cellular environment. Molecular Endocrinology 14(12):2024-2039

Day RN, Nordeen SK and Wan Y (1999) Visualizing protein-protein interactions in the nucleus of the living cell. Molecular Endocrinology 13(4):517-526