Publications

Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A and Wan Y (2012) Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates. Nature Communications, 3:1008. PDF

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A and Wan Y (2012) Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity. Genes & Development 26(12):1306-11. PDF

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA and Wan Y (2012) Fibroblast Growth Factor 21 Promotes Bone Loss by Potentiating the Effects of PPARγ. Proc Natl Acad Sci U S A.109(8):3143-8. PDF

Wei W and Wan Y (2011) Thiazolidinediones on PPARγ: the Roles in Bone Remodeling. PPAR Research, in press. PDF

Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM and Wan Y (2011) Osteoclast Progenitors Reside in PPARγ-Expressing Bone Marrow Cell Population. Molecular and Cellular Biology 31(23): 4692-4705. PDF, Supplementary Information

Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM and Wan Y (2011) Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by β-Catenin. Molecular and Cellular Biology, 31(23): 4706-4719. PDF, Supplementary Information

Wan Y (2010) PPARγ in Bone Homeostasis. Trends in Endocinology and Metabolism, 21:722-728 PDF

Wei W, Wang X, Yang M, Smith LC, Dechow PC and Wan Y (2010) PGC1b Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss. Cell Metabolism 11:503-516. PDF

Wan Y* and Evans RM (2010) Rosiglitazone Activation of PPARγ Suppresses Fractalkine Signalin. Journal of Molecular Endocrinology 44:135-142. (*corresponding author). PDF

Wan Y , Chong LW and Evans RM (2007) PPARγ Regulates Osteoclastogenesis in Mice. Nature Medicine 13:1496-1503. PDF ; Commentary in Cell Metabolism

Wan Y , Saghatelian A, Chong LW, Zhang CL, Cravatt BF and Evans RM (2007) Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk. Genes & Development 21:1895-1908. PDF ; HHMI news ; Editors' Choice in Science & STKE

Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y and Chrousos GP (2003) Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. Journal of Biological Chemistry 278(28):25651-25656

Wan Y and Nordeen SN (2003) Overlapping but distinct profiles of gene expression elicited by glucocorticoids and progestins. Recent Progress in Hormone Research 58:199-226

Wan Y and Nordeen SN (2002) Identification of genes differentially regulated by glucocorticoids and progestins using a Cre/ loxP mediated retroviral promoter-trapping strategy. Journal of Molecular Endocrinology 28(3):177-92

Wan Y and Nordeen SN (2002) Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells. Molecular Endocrinology 16(6):1204-1214

Nordeen SK , Housley PR, Wan Y and Day RN (2001) Application of Green Fluorescent Protein to study of dynamic protein-protein interactions and subcellular trafficking of steroid receptors. Methods in Molecular Biology, vol.176: Steroid Receptor Methods: Protocol and Assays: 179-199

Wan Y , Coxe KK, Thackray VG, Housley PR and Nordeen SK (2001) Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Molecular Endocrinology 15(1):17-31

Schaufele F, Chang C, Liu W, Baxter JD, Nordeen SK, Wan Y , Day RN and McDonnell DP (2000) Temporally distinct, ligand-specific recruitment of nuclear receptor interacting peptides and co-factors to the estrogen receptor in the cellular environment. Molecular Endocrinology 14(12):2024-2039

Day RN, Nordeen SK and Wan Y (1999) Visualizing protein-protein interactions in the nucleus of the living cell. Molecular Endocrinology 13(4):517-526