Publications
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Antibody Engineering and The MHC Class I-Related Receptor, FcRn
- (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice, Proc. Natl. Acad. Sci. USA , 106, 2788-2793.
- (2009) Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery, Traffic , 10, 600-614.
- (2007) Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy, Proc. Natl. Acad. Sci. USA , 104, 5889-5894.
- (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies, Proc. Natl. Acad. Sci. USA , 103, 18709-18714.
- (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels, Nature Biotech. , 23, 1283-1288.
- (2005) Conferring the binding properties of the mouse MHC Class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis, J. Mol. Biol. , 345, 1071-1081.
- (2004) Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level, Proc. Natl. Acad. Sci. USA , 101, 11076-11081.
- (2004) Visualizing the site and dynamics of IgG salvage by the MHC Class I-related receptor, FcRn, J. Immunol. , 172, 2021-2029.
- (2003) Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G, J. Mol. Biol. , 332, 901-913.
- (1999) Mapping of the site on human IgG1 for binding of the MHC class I related receptor, FcRn, Eur. J. Immunol. , 29, 2819-2825.
- (1997) Increasing the serum persistence of an IgG fragment by random mutagenesis, Nature Biotech. , 15, 637-640.
- (1997) Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG, J. Immunol. , 158, 2211-2217.
- (1996) Abnormally short serum half lives of IgGs in beta2-microglobulin deficient mice, Eur. J. Immunol. , 26, 690-696.
- (1989) Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli, Nature , 341, 544-546.
Autoimmune Disease and T cell Biology
- (2009) Autoantigen immunization at different sites reveals a role for anti-inflammatory effects of IFN-gamma in regulating susceptibility to experimental autoimmune encephalomyelitis , J. Immunol. , 182, 5268-5275.
- (2008) Targeting the neonatal Fc receptor for antigen delivery using engineered Fc fragments , J. Immunol. , 181, 7550-7561.
- (2007) Feedback regulation of murine autoimmunity via dominant anti-inflammatory effects of interferon gamma , J. Immunol. , 178, 134-144.
- (2005) The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis , Eur. J. Immunol. , 35, 299-304.
- (2003) T cell recognition of distinct peptide: I-Au conformers in murine experimental autoimmune encephalomyelitis , J. Immunol. , 171, 2467-2477.
- (2001) Crystal structure of a T cell receptor Va11 (AV11S5) domain: new canonical forms for the first and second complementarity determining regions , J. Mol. Biol. , 310, 689-698.
- (2001) Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis , Proc. Natl. Acad. Sci. USA , 98, 6818-6823.
- (2000) A role for the region encompassing the c” strand of a T cell receptor Va domain in T cell activation events , J. Immunol. , 165, 820-829.
- (1999) Molecular requirements for T cell recognition by an MHC Class II restricted T cell receptor: the involvement of the fourth hypervariable loop of the Va domain , J. Exp. Med. , 189, 509-519.
- (1995) Crystal structure of the Va domain of a T cell antigen receptor , Science , 270, 1821-1824.
Fluorescence Microscopy
- (2009) Improved single particle localization accuracy with dual objective multifocal plane microscopy , Optics Express , 17, 6881-6898.
- (2009) A resolution measure for three-dimensional microscopy , Optics Com. , 282, 1751-1761.
- (2009) Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery , Traffic , 10, 600-614.
- (2008) High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells , Biophys. J. , 95, 6025-6043.
- (2007) Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy, , Proc. Natl. Acad. Sci. USA , 104, 5889-5894.
- (2006) Simultaneous imaging of several focal planes in fluorescence microscopy for the study of cellular dynamics in 3D , Proc. SPIE. , 6090, 115-121.
- (2006) Beyond Rayleigh’s criterion: A resolution measure with application to single-molecule microscopy , Proc. Natl. Acad. Sci. USA , 103, 4457-4462.
- (2006) A stochastic analysis of performance limits for optical microscopes , Multidim. Sys. Sig. Proc. , 15, 27-57.
- (2005) Noise suppression of point spread functions and its influence on deconvolution of three dimensional fluorescence microscopy image sets , J. Microscopy , 217, 93-108.
- (2005) State Space Realization of a three-dimensional image set with application to noise reduction of fluorescent microscopy images of cells, , Multidim. Sys. Sig. Proc. , 16, 7-47.
- (2004) Exocytosis of IgG as mediated by the receptor, FcRn: An analysis at the single-molecule level , Proc. Natl. Acad. Sci. USA , 101, 11076-11081.
- (2004) Simultaneous imaging of different focal planes in fluorescence microscopy for the study of cellular dynamics in three dimensions. , IEEE Trans. Nanobio. , 3, 237-242.
- (2004) Localization accuracy in single-molecule microscopy , Biophys. J. , 86, 1185-1200. Please see MIATool for more information.
Signal Processing
- (2006) The Cramer Rao lower bound for bilinear systems , IEEE Trans. Sig. Proc. , 54, 1666-1680.
- (2005) The Cramer Rao lower bound for parameter estimation in nonlinear systems , IEEE Sig. Proc. Letts. , 12, 855-858.
- (2005) State space realization of a three-dimensional image set with application to noise reduction in fluorescent microscopy images of cells , Multidim. Sys. Sig. Proc. , 16, 7-48.
- (2004) Approximation of trajectories of nonlinear systems by iterates of systems with linear state dynamics , Sys. Cont. Letts. , 51, 377-381.
- (2003) Calculations of the Fisher information matrix for multidimensional data sets , IEEE Trans. on Sig. Proc. , 51(10), 2679–2691.
- (2002) Achievable accuracy of parameter estimation for multidimensional NMR experiments , J. Mag. Reson. , 157, 1-16.
- (2002) The Fisher information matrix for linear systems , Sys. Contr. Letts. , 47, 221–226.
Surface Plasmon Resonance (SPR)
- (2003) Analysis of exponential data using a non-iterative technique: application to surface plasmon experiments , Anal. Biochem. , 312, 57-65.
- (2002) Compensation for loss of ligand activity in surface plasmon resonance experiments , Anal. Biochem. , 306, 228-236.
- (1999) The influence of signal noise on the accuracy of kinetic constants measured by surface plasmon resonance experiments. , Anal. Biochem. , 271, 70-80. Please see SPRTool for more information.
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