Ward Lab

Publications

List of selected publications (sorted by Category).
Complete list of publications (sorted by Year)

2013

231   Chao, J., Ram, S., Ward, E. S., Ober, R. J. Ultrahigh accuracy imaging modality for super-localization microscopy. Nature Methods, published online, 1548-7105, 2013. Journal URL —

230   Chao, J., Ram, S., Ward, E. S., Ober, R. J. Two approximations for the geometric model of signal amplification in an electron-multiplying charge-coupled device detector. SPIE International Symposium on Biomedical and Optics (BiOs), 858905-858905-7, 2013. Journal URL —

229   Gan, Z., Ram, S., Ober, R. J., Ward, E. S. Using Multifocal Plane Microscopy to Reveal Novel Trafficking Processes on the Recycling Pathway. Journal of Cell Science, Article In Press, 2013. Journal URL — PubMed pdf-icon

2012

228   Ram, S., Kim, D., Ward, E. S., Ober, R. J. 3D Single Molecule Tracking with Multifocal Plane Microscopy Reveals Rapid Intercellular Transferrin Transport at Epithelial Cell Barriers. Biophysical Journal, 103(7): 1594-1603, 2012. Journal URL — PubMed pdf-icon

227   Zheng, J., Umikawa, M., Cui, C., Li, J., Chen, X., Zhang, C., Huynh, H., Kang, X., Silvany, R., Wan, X., Ye, J., Puig Cantó, A., Chen, S., Wang, H., Ward, E. S., Zhang, C. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature, 485: 656–660, May 31, 2012. Journal URL — PubMed pdf-icon

226   Ward, E. S., Ober, R. J. The diverse roles of FcRn: implications for antibody engineering. Therapeutic Proteins: strategies to modulate their plasma half-lives, John Wiley & Sons, May 15, 2012. Chapter URL

225   Chao, J., Ward, E. S., and Ober, R. J. Localization accuracy in single molecule microscopy using electron-multiplying charge-coupled device cameras. Proceedings of the SPIE, 8227: 82271P, 2012. Journal URL — [NIHMSID: 378988] — Full text pdf-icon

224   Wong, Y., Lin, Z., Ober, R. J. Effect of time discretization on the limit of the accuracy of parameter estimation for moving single molecules imaged by fluorescence microscopy. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 1228-1231, May 2012, Barcelona, Spain. Journal URL — Full text pdf-icon

223   Cohen, E. A. K., Ober, R. J. Image Registration error analysis with applications in single molecule microscopy. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 996 - 999, May 2012, Barcelona, Spain. Journal URL — [NIHMSID: 378553] — Full text pdf-icon

222   Ram, S., Ward, E. S., Ober, R. J. 3D single molecule tracking and superresolution microscopy using multifocal plane microscopy. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 914 - 915, May 2012, Barcelona, Spain. Journal URL — [NIHMSID: 380600] — Full text pdf-icon

221   Ram, S., Ward, E. S., Ober, R. J. A stochastic analysis of distance estimation approaches in single molecule microscopy - quantifying the resolution limits of photon-limited imaging systems Multidimensional Systems and Signal Processing, Article in press, 2012. Journal URL — [NIHMSID: 380603] — Full text pdf-icon

220   Chao, J., Ward, E. S., and Ober, R. J. Fisher information matrix for branching processes with application to electron-multiplying charge-coupled devices. Multidimensional Systems and Signal Processing, 23: 349-379, 2012. Journal URL — [NIHMSID: 379432] — Full text pdf-icon

2011

219   Patel, D., Puig-Canto, A., Challa, D. K., Montoyo, H. P., Ober, R. J., and Ward, E. S. Neonatal Fc receptor blockade by Fc engineering amerliorates arthritis in a murine model. Journal of Immunology, 187: 1015-1022, 2011. Journal URL — PubMed pdf-icon — [PMID: 21690327]

218   Wong, Y., Lin, Z., and Ober, R. J. Limit of the accuracy of parameter estimation for moving single molecules imaged by fluorescence microscopy. IEEE Transactions on Signal Processing, 59: 895-911, 2011. Journal URL — [NIHMSID: 380241] — Full text pdf-icon

2010

217   Chao, J., Ward, E. S., and Ober, R. J. A software framework for the analysis of complex microscopy image data. IEEE Transactions on Information Technology in Biomedicine, 14: 1075-1087, 2010. Journal URL — PubMed — [PMID: 20423810] — [NIHMSID: 378364] — Full text pdf-icon

216   Ram, S., Prabhat, P., Chao, J., Ward, E. S., and Ober, R. J. Three-dimensional single molecule tracking of quantum-dot labeled antibody molecules using multifocal plane microscopy, Proceedings of the SPIE, 7575: 75750J, 2010. Journal URL — [NIHMSID: 380601] — Full text pdf-icon

215   Abraham, A. V., Ram, S., Chao, J., Ward, E. S., and Ober, R. J. Comparison of estimation algorithms in single-molecule localization. Proceedings of the SPIE, 7570: 757004, 2010. Journal URL — Full text pdf-icon

214   Chao, J., Ward, E. S., Ober, R. J., Fisher information for EMCCD imaging with application to single molecule microscopy. the Forty Fourth Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 1085-1089, 2010, Pacific Grove, CA. Journal URL — [NIHMSID: 378746] — Full text pdf-icon

213   Maverakis, E., Menezes, J.S., Ametani, A., Han, M., Stevens, D. B., He, Y., Wang, Y., Ono, Y., Miyamura, Y., Lam, K.S., Ward, E. S., Sercarz, E. E., Molecular mimics can induce a nonautoaggressive repertoire that preempts induction of autoimmunity. Proceedings of the National Academy of Sciences, USA, 107: 2550-2555, 2010. Journal URL — PubMed — [PMID: 20133742]

2009

212   Abraham, A. V., Ram, S., Chao, J., Ward, E. S., and Ober, R. J., Quantitative study of single molecule location estimation techniques. Optics Express, 17: 23352-23373, 2009. Journal URL — PubMed — [PMCID: 2813811]

211   Chao, J., Ram, S., Ward, E. S., and Ober, R. J., A comparative study of high resolution microscopy imaging modalities using a three-dimensional resolution measure. Optics Express, 17:24377-24402, 2009. Journal URL — PubMed — [PMID: 20052148] — [NIHMSID: 378541]

210   Ward, E. S., and Ober, R. J., Multi-tasking by exploitation of intracellular transport functions: the many faces of FcRn. Advances in Immunology, 103: 77-115, 2009. Journal URL — PubMed — [PMID: 19755184]

209   Chao, J., Ram, S., Ward, E. S., and Ober, R. J., A 3D resolution measure for optical microscopy. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 1115-1118, June 2009, Boston, MA. Journal URL — Full text pdf-icon

208   Pastor, S., Minguela, A., Mi, W., and Ward, E. S., Autoantigen Immunization at Different Sites Reveals a Role for Anti – Inflammatory Effects of IFN-gamma in Regulating Susceptibility to Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 182: 5268-5275, 2009. Journal URL — PubMed — [PMCID: PMC2766852]

207   Ram, S., Prabhat, P., Ward, E. S., and Ober, R. J., Improved single particle localization accuracy with dual objective multifocal plane microscopy. Optics Express, 17: 6881- 6898, 2009. Journal URL — PubMed — [PMCID: PMC2720637]

206   Chao, J., Ram, S., Abraham, A. V., Ward, E. S., and Ober, R. J., A resolution measure for three - dimensional microscopy. Optics Communications, 282: 1751-1761, 2009. Journal URL — [NIHMSID: 96293]

205   Ram, S., Prabhat, P., Ward, E. S., and Ober, R. J., Dual objective fluorescence microscopy for single molecule imaging applications. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVI. SPIE International Society for Optical Engineering, 7184: 7184-0C, 2009. Journal URL — [NIHMSID: 169813] — Full text pdf-icon

204   Montoyo, HP., Vaccaro, C., Hafner, M., Ober, R. J., Mueller, W., and Ward, E. S., Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proceedings of the National Academy of Sciences USA, 106: 2788-2793, 2009. Journal URL — PubMed — [PMCID: PMC2650344]

203   Gan, Z., Ram, S., Vaccaro, C., Ober, R. J., and Ward, E. S., Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery. Traffic, 10: 600-614, 2009. Journal URL — PubMed — [NIHMSID: 134016]

2008

202   Mi, W., Wanjie, S., Lo, S. T., Gan, Z., Pickl-Herk, B., Ober, R. J., and Ward, E. S., Targeting the neonatal Fc receptor for antigen delivery using engineered Fc fragments. Journal of Immunology, 181: 7550-7561, 2008. Journal URL — PubMed — [PMCID: PMC2738423]

201   Ram, S., Prabhat, P., Chao, J., Ward, E. S., and Ober, R. J., High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells. Biophysical Journal, 95: 6025-6043, 2008. Journal URL — PubMed — [PMCID: PMC2599831]

200   Ram, S., Prabhat, P., Chao, J., Abraham, A. V., Ward, E. S., and Ober, R. J., Localizing single molecules in three dimensions — a brief review. In Proceedings of the 42nd Asilomar conference on Signals, Systems, and Computers (invited talk), 64-66, Pacific Grove, CA, October 26-29, 2008. Journal URL — [NIHMSID: 169475] — Full text pdf-icon

199   Chao, J., Ram, S., Ward, E. S., and Ober R. J., 3D resolution measure for multifocal plane microscopy. In Proceedings of the 2008 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 1339-1342, May 14-17, 2008. Journal URL — Full text pdf-icon

198   Chao, J., Ram, S., Abraham, A., Ward, E. S., and Ober, R. J. Resolution in 3D in multifocal plane microscopy. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XV. SPIE International Symposium on Biomedical and Optics (BiOs), 6861: 6861-0Q, 2008. Journal URL — [NIHMSID: 169808] — Full text pdf-icon

197   Ram, S., Chao, J., Prabhat, P., Ward, E. S., and Ober, R. J. Overcoming the depth discrimination barrier in widefield microscopes: 3D single molecule tracking with high axial accuracy. In Single Molecule Spectroscopy and Imaging. SPIE International Symposium on Biomedical and Optics (BiOs), 6862: 6862-0O, 2008. Journal URL — [NIHMSID: 169810] — Full text pdf-icon

2007

196   Minguela, A., Pastor, S., Mi, W., Richardson, J. A., and Ward, E. S. Feedback regulation of murine autoimmunity via dominant anti-inflammatory effects of interferon gamma. Journal of Immunology, 178: 134-144, 2007. Journal URL — PubMed — [PMID: 17182548]

195   Lambracht-Washington, D., O'Connor, K. C., Cameron, E., Jowdry, A., Ward, E. S., Frohman, E., Racke, M. K., and Monson, N. L. Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting multiple sclerosis. Journal of Neuroimmunology, 186: 164-176, 2007. Journal URL — PubMed — [PMCID: PMC2709235]

194   Prabhat, P., Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R. J., and Ward, E. S. Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, using multifocal plane microscopy. Proceedings of the National Academy of Sciences, USA, 104: 5889-5894, 2007. Journal URL — PubMed — [PMCID: PMC1851587]

193   Ram, S., Prabhat, P., Chao, J., Ward, E. S., and Ober, R. J. Resolution beyond Rayleigh's criterion: a modern resolution measure with applications to single molecule imaging. In Proceedings of the 2007 IEEE, Dallas Engineering in Medicine and Biology, 110-113, 2007. Journal URL — Full text pdf-icon

192   Chao, J., Long, P, Ward, E. S., and Ober, R. J. Design and application of the Microscopy Image Analysis Tool. In Proceedings of the 2007 IEEE, Dallas Engineering in Medicine and Biology, 94-97, 2007. Journal URL — Full text pdf-icon

191   Ram, S., Chao, J., Prabhat, P., Abraham, A., Ward, E. S., and Ober, R. J. Breaking resolution limits: advances and challenges in single molecule microscopy. Proceedings of the 41st Asilomar conference on Signals, Systems, and Computers, 1284-1287, Pacific Grove, CA, November 4-7, 2007. Journal URL — Full text pdf-icon

190   Ram, S., Ward, E. S., and Ober, R. J. Breaking the resolution barrier in optical microscopy: a new resolution measure with applications to single molecule imaging. In Proceedings of the 2007 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 928-931, Metro Washington DC, April 12-15, 2007. Journal URL — Full text pdf-icon

189   Ram, S., Chao, J., Prabhat, P., Ward, E. S., and Ober, R. J. A novel approach to determining the three-dimensional location of microscopic objects with applications to 3D particle tracking. Proceedings of SPIE on Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIV, 6443: 6443-0C, 2007. Journal URL — Full text pdf-icon

188   Ram, S., Abraham, A. V., Ward, E. S., and Ober, R. J. A novel 3D resolution measure for optical microscopes with applications to single molecule imaging. Ultrasensitive and Single-Molecule Detection Technologies II. SPIE International Symposium on Biomedical Optics (BiOS), 6444: 6440-D9, 2007. Journal URL — Full text pdf-icon

2006

187   Zou, Q., Lin, Z., and Ober, R. J. The Cramer-Rao lower bound for bilinear systems. IEEE Transactions on Signal Processing, 54:1666-1680, 2006. Journal URL — Full text pdf-icon

186   Ram, S., Ward, E. S., and Ober, R. J. A stochastic analysis of performance limits for optical microscopes. Multidimensional Systems and Signal Processing, 17:27-57, 2006. Journal URL — Full text pdf-icon

185   Ram, S., Ward, E. S., and Ober, R. J. Beyond Rayleigh's criterion: a resolution measure with application to single-molecule microscopy. Proceedings of the National Academy of Sciences, USA, 103: 4457-4462, 2006. Journal URL — PubMed

184   Ram, S., Ward, E. S., and Ober, R. J. A novel resolution measure for optical microscopes: stochastic analysis of the performance limits. In Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging: Macro to Nano, 770-773, Arlington, VA, April 6-9, 2006. Journal URL — Full text pdf-icon

183   Pastor, S., Vaccaro, C. G., Minguela, A., Ober, R. J., and Ward, E. S. Analyses of TCR clustering at the T cell-antigen-presenting cell interface and its impact on the activation of naive CD4+ T cells. International Immunology, 18: 1615-1625, 2006. Journal URL — PubMed

182   Vaccaro, C., Bawdon, R., Wanjie, S., Ober, R. J., and Ward, E. S. Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proceedings of the National Academy of Sciences, USA, 103: 18709-18714, 2006. Journal URL — PubMed

181   Ram, S., Ward, E. S., and Ober, R. J. A novel stochastic resolution criterion for fluorescence microscopes. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIII. SPIE the International Society for Optical Engineering, 6090: 6090-0J, 2006. Journal URL — Full text pdf-icon

180   Prabhat, P., Ram, S., Ward, E. S., and Ober, R. J. Simultaneous imaging of several focal planes in fluorescence microscopy for the study of cellular dynamics in 3D. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIII. SPIE the International Society for Optical Engineering, 6090: 6090-0L, 2006. Journal URL — Full text pdf-icon

179   Ram, S., Ward, E. S., and Ober, R. J. Resolution of optical microscope redefined. Biophotonics international, 13: 42-45, 2006. Journal URL — Full text pdf-icon

2005

178   Ober, R. J., Lai, X., Lin, Z., and Ward, E. S. State space realization of a three-dimensional image set with application to noise reduction of fluorescent microscopy images of cells. Multidimensional Systems and Signal Processing, 16: 7-47, 2005. Journal URL

177  Huang, J. C., Ober, R. J., and Ward, E. S. The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis. European Journal of Immunology, 35: 299-304, 2005. Journal URL — PubMed

176   Ram, S., Ward, E. S., and Ober, R. J. How accurately can a single molecule be localized in three dimensions using a fluorescence microscopy? In Imaging, Manipulation and Analysis of Biomolecules, Cells and Tissues II. SPIE International Symposium on Biomedical Optics (BiOS) 2005, 5699: 426-435, 2005. Journal URL — Full text pdf-icon

175   Zhou, J., Mateos, F., Ober, R. J., and Ward, E. S. Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. Journal of Molecular Biology, 345: 1071-1081, 2005. Journal URL — PubMed

174   Lin, Z., Zou, Q., Ward, E. S., and Ober, R. J. Cramer-Rao lower bound for parameter estimation in nonlinear systems. IEEE Signal Processing Letters, 12: 855-858, 2005. Journal URL

173   Vaccaro, C., Zhou, J., Ober, R. J., and Ward, E. S. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nature Biotechnology, 23: 1283-1288, 2005. Journal URL — PubMed

172   Lai, X., Ward, E. S., Lin, Z., and Ober, R. J. Three-dimensional state space realization algorithm: noise suppression of fluorescence microscopy images and point spread functions. In Three-dimensional and multidimensional microscopy: Image Processing and Acquisition XII. SPIE International Symposium on Biomedical Optics (BiOs) 2005, 5701: 53-60, 2005. Journal URL — Full text pdf-icon

171   Lin, Z, Zou, Q., and Ober, R. J. The CRLB for BIlinear systems and its biomedical applications. In Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS 2005), 2: 1338-1341, 2005. Journal URL

170   Ober, R. J., Lin, Z., and Zou, Q. On the identifiability of bilinear systems. In Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS 2005), 4: 3769-3772, 2005. Journal URL

169   Ward, E. S., Martinez, C., Vaccaro, C., Zhou, J., Tang, Q., and Ober, R. J. From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. Molecular Biology of the Cell, 16: 2028-2038, 2005. Journal URL — PubMed

168   Lai, X., Lin, Z., Ward, E. S., and Ober, R. J. Noise suppression of point spread functions and its influence on deconvolution of three-dimensional fluorescence microscopy image sets. Journal of Microscopy, 217: 93-108, 2005. Journal URL

2004

167   Ober, R. J., Ram, S., and Ward, E. S. Localization accuracy in single-molecule microscopy. Biophysical Journal, 86: 1185-1200, 2004. Journal URL — PubMed

166   Ober, R. J., Martinez, C., Vaccaro, C., Zhou, J., and Ward, E. S. Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. Journal of Immunology, 172: 2021-2029, 2004. Journal URL — PubMed

165   Hunt, L. R., Sally Ward, E., and Ober, R. J. Approximation of trajectories of non-linear systems by iterates of systems with linear state dynamics. Systems and Control Letters, 51: 377-381, 2004. Journal URL

164   Ober, R. J., Martinez, C., Lai, X., Zhou, J., and Ward, E. S. Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proceedings of the National Academy of Sciences, USA, 101: 11076-11081, 2004. Journal URL — PubMed

163   Prabhat, P., Ram, S., Ward, E. S., and Ober, R. J. Simultaneous imaging of different focal planes in fluorescence microscopy for the study of cellular dynamics in three dimensions. IEEE Transactions on Nanobioscience, 3: 237-242, 2004. Journal URL — PubMed — Full text pdf-icon

162   Ram, S., Ward, E. S., and Ober, R. J. How accurately can a single molecule be localized when imaged through an optical microscope? In Proceedings of the IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 1087-1090, 2004. Journal URL

161   Ober, R. J., Lai, X., Lin, Z., and Ward, E. S. A state space approach to noise reduction of 3D fluorescent microscopy images. In Proceedings of the IEEE International Conference on Image Processing (ICIP '04), 1153-1156, 2004. Journal URL

160   Ward, E. S. Acquiring maternal immunoglobulin: different receptors, similar functions. Immunity, 20: 507-508, 2004. Journal URL — PubMed

159   Huang, J. C., Vestberg, M., Minguela, A., Holmdahl, R., and Ward, E. S. Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers. International Immunology, 16: 283-293, 2004. Journal URL — PubMed

158   Ober, R. J. and Ward, E. S. MIATool: a software environment to analyze fluorescence microscopy image sets, 2004. Software URL

2003

157   Ober, R. J., Caves, J., and Ward, E. S. Analysis of exponential data using a noniterative technique: application to surface plasmon experiments. Analytical Biochemistry, 312: 57-65, 2003. Journal URL — PubMed

156   Ward, E. S., Zhou, J., Ghetie, V., and Ober, R. J. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans. International Immunology, 15: 187-195, 2003. Journal URL — PubMed

155   Zhou, J., Johnson, J. E., Ghetie, V., Ober, R. J., and Ward, E. S. Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G. Journal of Molecular Biology, 332: 901-913, 2003. Journal URL — PubMed

154   Ober, R. J., Zou, Q., and Lin, Z. Calculation of the Fisher information matrix for multidimensional data sets. IEEE Transactions on Acoustics, Speech, and Signal Processing, 51: 2679-2691, 2003. Journal URL

153   Lin, Z., Zou, Q., and Ober, R. J. The Fisher information matrix for two-dimensional data sets. In Proceedings of the IEEE International Conference on Acoustics, Speech, and Signal Processing, 3: 453-456, 2003. Journal URL

152   Zou, Q., Lin, Z., and Ober, R. J. The Fisher information matrix for two-dimensional separable-denominator continuous systems. In Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS 2003), 3: 714-717, 2003. Journal URL

151   Huang, J. C., Han, M., Minguela, A., Pastor, S., Qadri, A., and Ward, E. S. T cell recognition of distinct peptide:I-Au conformers in murine experimental autoimmune encephalomyelitis. Journal of Immunology, 171: 2467-2477, 2003. Journal URL — PubMed

150   Braciak, T., Pedersen, B., Chin, J., Hsiao, C., Ward, E. S., Maricic, I., Jahng, A., Graham, F., Gauldie, J., Sercarz, E., and Kumar, V. Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the V8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10. Journal of Immunology, 170: 765-774, 2003. Journal URL — PubMed

149   Cianga, P., Cianga, C., Cozma, L., Ward, E. S., and Carasevici, E. The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Human Immunology, 64: 1152-1159, 2003. Journal URL — PubMed

148   Ober, R. J. and Ward, E. S. SPRTool: a software environment to analyze optical biosensor data for the determination of interaction constants of protein-protein (or other macromolecule) interaction constants, 2003. Software URL

2002

147    Hanzon, B. and Ober, R. J. State-space calculations for discrete probability densities. Linear Algebra and Its Applications, 350: 67-87, 2002.      Journal URL  http://dx.doi.org/10.1016/S0024-3795(02)00268-9

146    Ramakrishna, V., Ober, R. J., Flores, K., and Rabitz, H. Control of a coupled two-spin system without hard pulses. Phys. Review A, 65: 063405, 2002.      Journal URL       http://dx.doi.org/10.1103/PhysRevA.65.063405

145    Ober, R. J. and Ward, E. S. Compensation for loss of ligand activity in surface plasmon resonance experiments. Analytical Biochemistry, 306: 228-236, 2002.      Journal URL        http://dx.doi.org/doi:10.1006/abio.2002.5716   PubMed

144    Ober, R. J., Lin, Z., Ye, H., and Ward, E. S. Achievable accuracy of parameter estimation for multidimensional NMR experiments. Journal of Magnetic Resonance, 157:1-16, 2002      Journal URL  http://dx.doi.org/doi:10.1006/jmre.2002.2560   PubMed

143    Ober, R. J. The Fisher information matrix for linear systems. Systems & Control Letters, 47: 221-226, 2002.   Journal URL    http://dx.doi.org/doi:10.1016/S0167-6911(02)00190-1

142    Deng, C., Minguela, A., Hussain, R. Z., Lovett-Racke, A. E., Radu, C., Ward, E. S., and Racke, M. K. Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis. Journal of Immunology, 168: 4511-4518, 2002.      Journal URL        http://www.jimmunol.org/cgi/content/abstract/168/9/4511   PubMed    

141    Backlund, J., Treschow, A., Firan, M., Malmstrom, V., Issazadeh-Navikas, S., Ward, E. S., and Holmdahl, R. Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection. European Journal of Immunology, 32: 1773-1783, 2002.    Journal URL   http://dx.doi.org/10.1002/1521-4141(200206)32:6%3c1773::AID-IMMU1773%3e3.0.CO;2-Z   PubMed

140    Spiekermann, G. M., Finn, P. W., Ward, E. S., Dumont, J., Dickinson, B. L., Blumberg, R. S., and Lencer, W. I. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. The Journal of Experimental Medicine, 196: 303-310, 2002.      Journal URL    http://dx.doi.org/doi:10.1084/jem.20020400   PubMed

139    Dall'Acqua, W. F., Woods, R. M., Ward, E. S., Palaszynski, S. R., Patel, N. K., Brewah, Y. A., Wu, H., Kiener, P. A., and Langermann, S. Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences. Journal of Immunology, 169: 5171-5180, 2002.   Journal URL   http://www.jimmunol.org/cgi/content/abstract/169/9/5171   PubMed   

138    He, X. L., Radu, C., Sidney, J., Sette, A., Ward, E. S., and Garcia, K. C. Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity, 17: 83-94, 2002.      Journal URL     http://dx.doi.org/doi:10.1016/S1074-7613(02)00340-0    PubMed

137    Ghetie, V. and Ward, E. S. Transcytosis and catabolism of antibody. Immunology Research, 25: 97-113, 2002.      Journal URL     PubMed

2001

136    Garcia, K. C., Radu, C. G., Ho, J., Ober, R. J., and Ward, E. S. Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences, USA, 98: 6818-6823, 2001.      Journal URL http://dx.doi.org/doi:10.1073/pnas.111161198

135    Firan, M., Bawdon, R., Radu, C., Ober, R. J., Eaken, D., Antohe, F., Ghetie, V., and Ward, E. S. The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. International Immunology, 13: 993-1002, 2001.      Journal URL  http://dx.doi.org/doi:10.1093/intimm/13.8.993

134    Hanzon, B. and Ober, R. J. A state-space calculus for rational probability density functions and applications to non-Gaussian filtering. SIAM Journal on Control and Optimization, 40: 724-740, 2001.      Journal URL     http://dx.doi.org/10.1137/S036301299731610X

133    Ober, R. J., Radu, C. G., Ghetie, V., and Ward, E. S. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. International Immunology, 13: 1551-1559, 2001.      Journal URL     http://dx.doi.org/doi:10.1093/intimm/13.12.1551

132    Ramakrishna, V., Ober, R. J., Flores, K. L., and Rabitz, H. Constructive control of a spin system via periodic control.  In Proceedings of the 40th IEEE Conference on Decision and Control, 1: 292-297, 2001.      Journal URL     Local PDF     ober2001e     http://dx.doi.org/10.1109/.2001.980115

131    Anderton, S. M., Radu, C. G., Lowrey, P. A., Ward, E. S., and Wraith, D. C. Negative selection during the peripheral immune response to antigen. Journal of Experimental Medicine, 193: 1-11, 2001.      Journal URL     

130    Kumar, V., Maglione, J., Thatte, J., Pederson, B., Sercarz, E., and Ward, E. S. Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis. International Immunology, 13: 835-841, 2001.      Journal URL    

129    Machius, M., Cianga, P., Deisenhofer, J., and Ward, E. S. Crystal structure of a T cell receptor Valpha11 (AV11S5) domain: new canonical forms for the first and second complementarity determining regions. Journal of Molecular Biology, 310: 689-698, 2001.      Journal URL   http://dx.doi.org/doi:10.1006/jmbi.2001.4794

128    Qadri, A. and Ward, E. S. Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death. European Journal of Immunology, 31: 3825-3832, 2001.      Journal URL   http://dx.doi.org/10.1002/1521-4141(200112)31:12%3c3825::AID-IMMU3825%3e3.0.CO;2-O

127    Ramakrishna, V., Ober, R. J., and Rabitz, H. Control of some quantum systems-the role of phases.  Proceedings of the IFAC-NOLCOS, 1495-1502, 2001.

2000

126    Ramakrishna, V., Ober, R. J., Sun, X., Steuernagel, O., Botina, J., and Rabitz, H. Explicit generation of unitary transformations in a single atom or molecule. Phys. Rev. A, 61: 032106, 2000.      Journal URL     http://dx.doi.org/10.1103/PhysRevA.61.032106  

125    Qadri, A., Radu, C. G., Thatte, J., Cianga, P., Ober, B. T., Ober, R. J., and Ward, E. S. A role for the region encompassing the c" strand of a TCR V alpha domain in T cell activation events. Journal of Immunology, 165: 820-829, 2000.  Journal URL    http://www.jimmunol.org/cgi/content/abstract/165/2/820   

124    Gheondea, A. and Ober, R. J. A note on the existence, uniqueness, and symmetry of par-balanced realizations for infinite dimensional systems. Integral Equations and Operator Theory, 37: 423-436, 2000.      Journal URL     http://dx.doi.org/doi:10.1007/BF01192830

123    Ramakrishna, V., Flores, K., Rabitz, H., and Ober, R. J. Quantum control by decomposition of SU(2). Phys. Rev. A, 6205: 3409, 2000.       Journal URL http://dx.doi.org/10.1103/PhysRevA.62.053409

122    Ober, R. J., Ramakrishna, V., and Ward, E. S. NMR spectroscopy: systems, transfer functions, reachability and other system theoretic notions.  In Proceedings of the 39th IEEE Conference on Decision and Control, 2: 1370-1375, 2000.     Journal URL     http://dx.doi.org/10.1109/CDC.2000.912048

121    Ramakrishna, V., Flores, K. L., Rabitz, H., and Ober, R. J. Constructive controllability for systems with drift motivated by and applied to quantum control. In Proceedings of the 39th IEEE Conference on Decisions and Control, 1: 955-960, 2000.    Journal URL    http://dx.doi.org/10.1109/CDC.1997.652447

120    Ghetie, V. and Ward, E. S. Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Annual Review of Immunology, 18: 739-766, 2000.      Journal URL       http://dx.doi.org/doi:10.1146/annurev.immunol.18.1.739

119    Radu, C. G., Anderton, S. M., Firan, M., Wraith, D. C., and Ward, E. S. Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers. International Immunology, 12: 1553-1560, 2000.      Journal URL      http://dx.doi.org/doi:10.1093/intimm/12.11.1553      

1999

118    Ober, R. J. An introduction to the shift realization for finite dimensional continuous time systems. International Journal of Control, 72: 332-344, 1999.  Journal URL  http://dx.doi.org/10.1080/002071799221145

117    Gheondea, A. and Ober, R. J. A Trace Formula for Hankel Operators. Proceedings of the American Mathematical Society, 127: 2007-2012, 1999.   Journal URL    

116    Gheondea, A. and Ober, R. J. Completely J-positive linear systems of finite order. Mathematische Nachrichten, 203: 75-101, 1999. 

115    Ober, R. J. and Ward, E. S. The choice of reference cell in the analysis of kinetic data using BIAcore. Analytical Biochemistry, 271: 70-80, 1999.      Journal URL  http://dx.doi.org/doi:10.1006/abio.1999.4129

114    Ober, R. J. and Ward, E. S. The influence of signal noise on the accuracy of kinetic constants measured by surface plasmon resonance experiments. Analytical Biochemistry, 273: 49-59, 1999.      Journal URL    http://dx.doi.org/doi:10.1006/abio.1999.4185

113    Ober, R. J., Ramakrishna, V., and Ward, E. S. On the role of reachability and observability in NMR experimentation. Journal of Mathematical Chemistry, 26: 15-26, 1999.      Journal URL           http://dx.doi.org/doi:10.1023/A:1019117424294

112    Thatte, J., Qadri, A., Radu, C., and Ward, E. S. Molecular requirements for T cell recognition by a major histocompatibility complex class II-restricted T cell receptor: the involvement of the fourth hypervariable loop of the Valpha domain. The Journal of Experimental Medicine, 189: 509-520, 1999.      Journal URL      

111    Aroeira, L. S., Mouton, C. G., Toran, J. L., Ward, E. S., and Martinez, C. Anti-Vbeta8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vbeta8+ T cell anergy. European Journal of Immunology, 29: 437-445, 1999.      Journal URL   http://dx.doi.org/10.1002/(SICI)1521-4141(199902)29:02<437::AID-IMMU437>3.0.CO;2-A

110    Qadri, A., Thatte, J., Radu, C. G., Ober, B., and Ward, E. S. Characterization of the interaction of a TCR alpha chain variable domain with MHC II I-A molecules. International Immunology, 11: 967-977, 1999.      Journal URL    http://dx.doi.org/doi:10.1093/intimm/11.6.967

109    Cianga, P., Medesan, C., Richardson, J. A., Ghetie, V., and Ward, E. S. Identification and function of neonatal Fc receptor in mammary gland of lactating mice. European Journal of Immunology, 29: 2515-2523, 1999.      Journal URL      http://dx.doi.org/10.1002/(SICI)1521-4141(199908)29:08<2515::AID-IMMU2515>3.0.CO;2-D

108    Kim, J. K., Firan, M., Radu, C. G., Kim, C. H., Ghetie, V., and Ward, E. S. Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn. European Journal of Immunology, 29: 2819-2825, 1999.      Journal URL      http://dx.doi.org/10.1002/(SICI)1521-4141(199909)29:09<2819::AID-IMMU2819>3.0.CO;2-6

107    Schuck, P., Radu, C. G., and Ward, E. S. Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1. Molecular Immunology, 36: 1117-1125, 1999.      Journal URL     http://dx.doi.org/doi:10.1016/S0161-5890(99)00093-0

1998

106    Ober, R. J. Asymptotic stabilization of infinite-dimensional systems which cannot be exponentially stabilized. Systems & Control Letters, 35: 61-63, 1998.      Journal URL  http://dx.doi.org/doi:10.1016/S0167-6911(98)00030-9

105    Hanzon, B. and Ober, R. J. Overlapping balanced canonical forms for various classes of linear systems. Linear Algebra and Its Applications, 281: 171-225, 1998.      Journal URL   http://dx.doi.org/doi:10.1016/S0024-3795(98)10056-3

104    Ramakrishna, V., Ober, R. J., and Rabitz, H. Explicit generation of states in quantum control.  Mathematical Theory of Network and Systems: Proceedings of the 98' MTNS, 1071-1073, 1998.  

103    Ober, R. J., Ward, E. S., and Ramakrishna, V. On the role of reachability in the analysis of NMR experiments.  Mathematical Theory of Network and Systems: Proceedings of the 98' MTNS, 1059-1062, 1998.     Journal URL     

102    Ober, R. J. and Ward, E. S. On the class of attainable multidimensional NMR spectra. Journal of Mathematical Chemistry, 22: 1-10, 1998.    Journal URL    http://dx.doi.org/doi:10.1023/A:1019167729379

101    Radu, C. G., Ober, B. T., Colantonio, L., Qadri, A., and Ward, E. S. Expression and characterization of recombinant soluble peptide: I-A complexes associated with murine experimental autoimmune diseases. Journal of Immunology, 160: 5915-5921, 1998.    Journal URL     

100    Medesan, C., Cianga, P., Mummert, M., Stanescu, D., Ghetie, V., and Ward, E. S. Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site. European Journal of Immunology, 28: 2092-2100, 1998.      Journal URL     http://dx.doi.org/10.1002/(SICI)1521-4141(199807)28:07<2092::AID-IMMU2092>3.0.CO;2-E

99      Borvak, J., Richardson, J., Medesan, C., Antohe, F., Radu, C., Simionescu, M., Ghetie, V., and Ward, E. S. Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. International Immunology, 10: 1289-1298, 1998.    Journal URL   http://dx.doi.org/10.1093/intimm/10.9.1289

1997

98      Hanzon, B. and Ober, R. J. Overlapping block-balanced canonical form and parametrizations:  the stable SISO case. SIAM Journal on Control and Optimization, 35: 228-242, 1997.    Journal URL   http://dx.doi.org/10.1137/S0363012993260549  

97      Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J., and Ward, E. S. Increasing the serum persistence of an IgG fragment by random mutagenesis. Nature Biotechnology, 15: 637-640, 1997.      Journal URL      http://dx.doi.org/doi:10.1038/nbt0797-637

96      Gheondea, A. and Ober, R. J. Spectral minimality of J-positive linear systems of finite order. In Operators, Systems and Linear Algebra, pages: 70-80, B.G. Teubner, 1997.   

95      Ober, R. J. and Ward, E. S. On the class of attainable multidimensional NMR spectra. Journal of Mathematical Chemistry, 22: 1-10, 1997.      Journal URL   http://dx.doi.org/10.1023/A:1019167729379

94      Ober, R. J. Another look at realization theory. In Proceedings of the 36th IEEE Conference on Decision and Control, 4: 3785-3790, 1997.      Journal URL    http://dx.doi.org/10.1109/CDC.1997.652447

93      Ward, E. S. and Qadri, A. Biophysical and structural studies of T cell receptors and ligands:  implications in T cell signaling. Current Opinions in Immunology, 9: 97-106, 1997      Journal URL  http://dx.doi.org/doi:10.1016/S0952-7915(97)80165-3

92      Ghetie, V. and Ward, E. S. FcRn: the MHC class I-related receptor that is more than an IgG transporter. Immunology Today, 18: 592-598, 1997.     Journal URL     http://dx.doi.org/doi:10.1016/S0167-5699(97)01172-9

91      Medesan, C., Matesoi, D., Radu, C., Ghetie, V., and Ward, E. S. Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. Journal of Immunology, 158: 2211-2217, 1997.   Journal URL    http://www.jimmunol.org/cgi/content/abstract/158/5/2211    

90      Li, H., Lebedeva, M. I., Ward, E. S., and Mariuzza, R. A. Dual conformations of a T cell receptor V alpha homodimer: implications for variability in V alpha V beta domain association. Journal of Molecular Biology, 269: 385-394, 1997.     Journal URL     http://dx.doi.org/doi:10.1006/jmbi.1997.1047

89      Kumar, V., Coulsell, E., Ober, B., Hubbard, G., Sercarz, E., and Ward, E. S. Recombinant T cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells. Journal of Immunology, 159: 5150-5156, 1997.      Journal URL   http://www.jimmunol.org/cgi/content/abstract/159/10/5150  

1996

88      Ober, R. J. and Wu, Y. Infinite dimensional continuous-time linear systems:stability and structure analysis. SIAM Journal on Control and Optimization, 34: 757-812, 1996.    Journal URL     http://dx.doi.org/10.1137/S0363012993245318

87      Ober, R. J. Balanced canonical forms. Identification, Adaptation, Learning: The Science of Learning Models from Data, pages: 120-179, Springer-Verlag, New York, 1996.   

86      Ober, R. J. On Stieltjes functions and Hankel operators. Systems & Control Letters, 27: 275-277, 1996.    Journal URL     http://dx.doi.org/10.1016/0167-6911(95)00066-6

85      Ober, R. J. and Ward, E. S. System theoretic formulation of NMR experiments. Journal of Mathematical Chemistry, 20: 47-65, 1996.      Journal URL   http://dx.doi.org/10.1007/BF01165155

84      Ober, R. J. System theoretic aspects of completely symmetric systems. In Operator Theory: Advances and Applications, pages: 233-262, Birkhaeuser Verlag, 1996.    

83      Filikov, A. V., Jones, J. R., Myasoedov, N. F., and Ward, E. S. Application of solid state catalytic hydrogen isotope exchange to the tritium labeling of lysozyme. Journal of Labelled Compounds and Radiopharmaceuticals, 36: 179-185, 1996.    Journal URL     http://dx.doi.org/DOI:10.1002/jlcr.2580360210

82      Ward, E. S. Production and manipulation of antibodies and T cell receptors using  recombinant DNA technology. Therapeutic Immunology, 335-346, 1996.    

81      Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y., and Ward, E. S. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. European Journal of Immunology, 26: 690-696, 1996.      Journal URL     http://dx.doi.org/10.1002/eji.1830260327

80      Popov, S., Hubbard, J. G., and Ward, E. S. A novel and efficient route for the isolation of antibodies that recognise T cell receptor V alpha(s). Molecular Immunology, 33: 493-502, 1996.   Journal URL     http://dx.doi.org/doi:10.1016/0161-5890(96)00020-X

79      Popov, S., Hubbard, J. G., Kim, J., Ober, B., Ghetie, V., and Ward, E. S. The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn. Molecular Immunology, 33: 521-530, 1996.      Journal URL     http://dx.doi.org/doi:10.1016/0161-5890(96)00004-1

78      Medesan, C., Radu, C., Kim, J. K., Ghetie, V., and Ward, E. S. Localization of the site of the IgG molecule that regulates maternofetal transmission in mice. European Journal of Immunology, 26: 2533-2536, 1996.      Journal URL     http://dx.doi.org/10.1002/eji.1830261038

1995

77     Ober, R. J. and Ward, E. S. Correcting for phase distortion of NMR spectra analyzed using singular-value decomposition of Hankel matrices. Journal of Magentic Resonance, 114: 120-123, 1995.      Journal URL    http://dx.doi.org/10.1006/jmra.1995.1116    

76      Ward, E. S. and Bebbington, C. R. Genetic manipulation and expression of antibodies. Monoclonal Antibodies, pages: 137-185, Hanser Publishers, 1995.    

75     Ghetie, V. and Ward, E. S. Genetic manipulation of antibodies:  from variable domains to constant regions. The Antibodies, pages: 169-211, Gordon and Breach, San Diego, 1995.   

74      Ward, E. S. VH shuffling can be used to convert an Fv fragment of anti-hen egg lysozyme specificity to one that recognizes a T cell receptor V alpha. Molecular Immunology, 32: 147-156, 1995.      Journal URL     http://dx.doi.org/doi:10.1016/0161-5890(94)00119-L

73      Kim, J. K., Tsen, M. F., Ghetie, V., and Ward, E. S. Evidence that the hinge region plays a role in maintaining serum levels of the murine IgG1 molecule. Molecular Immunology, 32: 467-475, 1995.      Journal URL    http://dx.doi.org/doi:10.1016/0161-5890(95)00019-B

72      Jahn, S., Roggenbuck, D., Niemann, B., and Ward, E. S. Expression of monovalent fragments derived from a human IgM autoantibody in E. coli. The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity. Immunobiology, 193: 400-419, 1995.     Journal URL     

71     Falcioni, F., Vidovic, D., Ward, E. S., Bolin, D., Singh, G., Shah, H., Ober, B., and Nagy, Z. A. Self tolerance to T cell receptor V beta sequences. The Journal of Experimental Medicine, 182: 249-254, 1995.    Journal URL     

70      Rosloniec, E. F., Brand, D. D., Whittington, K. B., Stuart, J. M., Ciubotaru, M., and Ward, E. S. Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis. Journal of Immunology, 155: 4504-4511, 1995.    Journal URL          

69      Fields, B. A., Ober, B., Malchiodi, E. L., Lebedeva, M. I., Braden, B. C., Ysern, X., Kim, J. K., Shao, X., Ward, E. S., and Mariuzza, R. A. Crystal structure of the V alpha domain of a T cell antigen receptor. Science, 270: 1821-1824, 1995.     Journal URL     http://dx.doi.org/DOI:10.1126/science.270.5243.1821

68      Ward, E. S. and Ghetie, V. The effector functions of immunoglobulins: implications for therapy. Therapeutic Immunology, 2: 77-94, 1995.    Journal URL

1994

67      Sefton, J. A. and Ober, R. J. Properties of optimally robust controllers. International Journal of Control, 59: 1191-1210, 1994.    Journal URL    http://dx.doi.org/10.1080/00207179408923127

66     Sefton, J. A. and Ober, R. J. Hankel norm approximation and control systems.In Proceedings of the 31st IEEE Conference on Decision and Control, 205: 1081-1120, 1994.      Journal URL          

65     Ober, R. J. and Fuhrmann, P. A. Diffeomorphisms between classes of linear systems. In Linear Algebra and its Applications, pages: 117-157, Springer Verlag, 1994.     

64      Fields, B. A., Ysern, X., Poljak, R. J., Shao, X., Ward, E. S., and Mariuzza, R. A. Crystallization and preliminary X-ray diffraction study of a bacterially produced T-cell antigen receptor V alpha domain. Journal of Molecular Biology, 239: 339-341, 1994.     Journal URL     http://dx.doi.org/doi:10.1006/jmbi.1994.1373

63      Kim, J. K., Tsen, M. F., Ghetie, V., and Ward, E. S. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. European Journal of Immunology, 24: 2429-2434, 1994.    Journal URL     http://dx.doi.org/10.1002/eji.1830241025

62      Kim, J. K., Tsen, M. F., Ghetie, V., and Ward, E. S. Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis. European Journal of Immunology, 24: 542-548, 1994.      Journal URL     

61     Kim, J. K., Tsen, M. F., Ghetie, V., and Ward, E. S. Catabolism of the murine IgG1 molecule: evidence that both CH2-CH3 domain interfaces are required for persistence of IgG1 in the circulation of mice. Scandinavian Journal of Immunology, 40: 457-465, 1994.      Journal URL     http://dx.doi.org/doi:10.1111/j.1365-3083.1994.tb03488.x

60     Ciubotaru, M. and Ward, E. S. Expression of soluble T-cell receptor fragments derived from a T-cell clone associated with murine collagen-induced arthritis. Immunology Letters, 43: 139-141, 1994.      Journal URL     http://dx.doi.org/doi:10.1016/0165-2478(94)00190-1 

1993

59      Fuhrmann, P. A. and Ober, R. J. A functional approach to LQG balancing. International Journal of Control, 57: 627-741, 1993.    Journal URL     http://dx.doi.org/10.1080/00207179308934410

58      Fuhrmann, P. A. and Ober, R. J. State space forrmulas for coprime factorizations. Operator Theory: Advances and Applications: Contributions to Operator Theory and its applications, Vol. 62, pp: 39-75,  Birkhaeuser Verlag Basel, 1993.    

57      Sefton, J. A. and Ober, R. J. On the gap metric and coprime factor perturbations. Automatica, 29: 723-734, 1993.     Journal URL     http://dx.doi.org/doi:10.1016/0005-1098(93)90066-3

56      Sefton, J. A. and Ober, R. J. Uncertainty in the weighted gap metric: A geometric approach. Automatica, 29: 1079-1100, 1993.    Journal URL     http://dx.doi.org/doi:10.1016/0005-1098(93)90108-6

55      Ober, R. J. and Wu, Y. Asymptotic Stability of Infinite-Dimensional Discrete-Time Balanced Realizations. SIAM Journal on Control and Optimization, 31: 1321-1339, 1993.      Journal URL      http://dx.doi.org/10.1137/0331062

54      Gerencser, L., Michaletzky, G., and Ober, R. J. Balancing for identification and control. Systems and Networks: Mathematical Theory and Applications-Proceedings of the International Symposium Mtns '93 Held in Regensburg, Germany, pages: 141-144, Akademie Verlag,  August 2-6, 1993.    

53      Ward, E. S. Antibody Engineering using E. coli as a host. Advances in Pharmacology, pages: 1-20, Academic Press, 1993.    

52      Winter, G. P. and Ward, E. S. Antibody Engineering. Clinical Aspects of Immunology, pages: 817-828, Blackwell Scientific Publications, Malden, 1993.    

1992

51      Sefton, J. A. and Ober, R. J. Graphs of linear systems and stabilization. In Kimura, H. and Kodama, S., eds., Recent Advances in Mathematical Theory of Systems, Control, Networks, and Signal Processing I, pages: 351-356, Mita Press, 1992.    

50      Sefton, J. A. and Ober, R. J. Hankel norm approximation and control systems. In Proceedings of the 31st IEEE Conference on Decision and Control, 1: 1030-1035, 1992.      Journal URL  

49      Fuhrmann, P. A. and Ober, R. J. A functional approach to LQG balancing. In Proceedings of the 31st IEEE Conference on Decision and Control, 1: 1036-1039, 1992.      Journal URL  

48     Hanzon, B. and Ober, R. J. Overlapping block-balanced canonical forms and parametrizations: the stable SISO case.  In Proceedings of the 31st IEEE Conference on Decision and Control, 3: 2835-2838, 1992.      Journal URL     

47      Ober, R. J. and Wu, Y. Stability analysis of infinite dimensional discrete and continuous time linear systems.  In Proceedings of the 31st IEEE Conference on Decision and Control, 4: 3436-3437, 1992.      Journal URL     

46      Ward, E. S. Antibody engineering: the use of Escherichia coli as an expression host. FASEB Journal, 6: 2422-2427, 1992.      Journal URL     

45      Borrebaeck, C. A., Malmborg, A. C., Furebring, C., Michaelsson, A., Ward, E. S., Danielsson, L., and Ohlin, M. Kinetic analysis of recombinant antibody-antigen  interactions: relation between structural domains and antigen binding. Biotechnology (N. Y.), 10: 697-698, 1992.      Journal URL   http://dx.doi.org/doi:10.1038/nbt0692-697

44      Ward, E. S. Secretion of T cell receptor fragments from recombinant Escherichia coli cells. Journal of Molecular Biology, 224: 885-890, 1992.      Journal URL  http://dx.doi.org/doi:10.1016/0022-2836(92)90455-S

43      Cumber, A. J., Ward, E. S., Winter, G., Parnell, G. D., and Wawrzynczak, E. J. Comparative stabilities in vitro and in vivo of a recombinant mouse antibody FvCys  fragment and a bisFvCys conjugate. Journal of Immunology, 149: 120-126, 1992.    Journal URL     

42      Ober, R. J. and Fuhrmann, P. A. Diffeomorphisms between manifolds of linear systems.  Proceedings SINS 92'. Symposium on Implicit and Nonlinear Systems: 139-146, 1992.

1991

41      Ober, R. J. Balanced parametrization of classes of linear systems. SIAM Journal on Control and Optimization, 29: 1251-1287, 1991.     Journal URL    http://dx.doi.org/doi:10.1137/0329065

40      Ober, R. J. and Sefton, J. A. Stability of control systems and graphs of linear systems. Systems & Control Letters, 17: 265-280, 1991.     Journal URL  http://dx.doi.org/doi:10.1016/0167-6911(91)90142-2

39      Wu, Y. and Ober, R. J. Asymptotic stability of infinite dimensional discrete-time balanced realizations.  In Proceedings of the 30th IEEE Conference on Decision and Control, 3: 3025-3030, 1991.      Journal URL     http://dx.doi.org/10.1109/CDC.1991.261101

38      Sefton, J. A. and Ober, R. J. Graphs of Linear Systems and Stabilization.  In Proceedings of the 30th IEEE Conference on Decision and Control, 1: 545-546, 1991.      Journal URL      http://dx.doi.org/10.1109/CDC.1991.261366

37     Ward, E. S. Expression and Secretion of T-Cell Receptor Va and Vß Domains using Escherichia coli as a Host. Scandinavian Journal of Immunology, 34: 215-220, 1991.      Journal URL         http://dx.doi.org/doi:10.1111/j.1365-3083.1991.tb01539.x

36      Howe, C. J. and Ward, E. S. DNA Sequencing. In Essential Molecular Biology:  A Practical Approach, pages. 157-183. Oxford University Press, IRL, 1991.   

35      Ward, E. S. Expression and purification of antibody fragments using Escherichia coli as a host. In Antibody Engineering:  A Practical Guide, pages: 121-137, Stockton Press, New York, 1991.

1990

34      Ober, R. J. and Montgomery-Smith, S. Bilinear transformation of infinite dimensional state-space systems and balanced realizations of nonrational transfer functions. SIAM Journal on Control and Optimization, 28: 438-465, 1990.     Journal URL     http://dx.doi.org/doi:10.1137/0328024

33      Ober, R. J. A Note on a System Theoretic Approach to a Conjecture by Peller-Khrushchev: The General Case. IMA J Math Control Info, 7:35-45, 1990.    Journal URL     http://dx.doi.org/doi:10.1093/imamci/7.1.35

32      De Mari, F. and Ober, R. J. Topological aspects of robust control. In Control of Uncertain Systems, pages: 57-67, Birkhaeuser, Boston, 1990.    

31      Sefton, J. A., Ober, R. J., and Glover, K. Robust stabilization in the presence of coprime factor perturbations. In Proceedings of the 29th IEEE Conference on Decision and Control, 3: 1197-1198, 1990.      Journal URL     http://dx.doi.org/10.1109/CDC.1990.203796

30     McGinnie, B. P., Ober, R. J., and Maciejowski, J. M. Balanced parametrization in time-series identification. In Proceedings of the 29th IEEE Conference on Decision and Control, 6: 3202-3203, 1990.      Journal URL     http://dx.doi.org/10.1109/CDC.1990.203380

29     Boulot, G., Eisele, J. L., Bentley, G. A., Bhat, T. N., Ward, E. S., Winter, G., and Poljak, R. J. Crystallization and preliminary X-ray diffraction study of the bacterially expressed Fv from the monoclonal anti-lysozyme antibody D1.3 and of its complex with the antigen, lysozyme. Journal of Molecular Biology, 213: 617-619, 1990.      Journal URL     http://dx.doi.org/doi:10.1016/S0022-2836(05)80248-7

28      Jones, P. T., Ward, E. S., Gussow, D., Griffiths, A. D., and Winter, G. Generating a repertoire  of antibody v genes and the selection and expression of antigen binding activities in E. coli. Protein  Engineering: Protein Design in Basic Research, Medicine, and Industry, pages:  229-234,  Spring-Verlag, 1990.     

1989

27     Ober, R. J. Connectivity properties of various classes of linear systems. International Journal of Control, 50: 2049-2073, 1989.    Journal URL  http://dx.doi.org/10.1080/00207178908953481          

26      Ober, R. J. and McFarlane, D. Balanced canonical forms for minimal systems: a normalized coprime factor approach. Linear Algebra and Its Applications, 122-124: 23-64, 1989.    Journal URL           http://dx.doi.org/doi:10.1016/0024-3795(89)90646-0

25      Ober, R. J. Stability and structural properties of infinite dimensional balanced realizations.  Proceedings of 5th IFAC Symposium on Control of Distributed Parameter Systems, 577-583, 1989.   

24      Gussow, D., Ward, E. S., Griffiths, A. D., Jones, P. T., and Winter, G. Generating binding activities from Escherichia coli by expression of a repertoire of immunoglobulin variable domains.  Cold Spring Harbor Symposium on Quantative Biology, 265-272, 1989.   

23      Ward, E. S., Gussow, D., Griffiths, A. D., Jones, P. T., and Winter, G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature, 341: 544-546, 1989.     Journal URL    http://dx.doi.org/doi:10.1038/341544a0

22      Ward, E. S., Gussow, D., Griffiths, A. D., Kiener, P. A., and Winter, G. Expression and secretion of repertoires of VH domains in Escerichia coli: isolation of antigen binding activities. Progress in Immunology, pages: 1144-1151, Springer-Verlag, Berlin, 1989.   

21      Howe, C. J. and Ward, E. S. Nucleic Acids Sequencing:  A Practical Approach Oxford University Press, IRL, 1989.

20      Ward, E. S. and Howe, C. J. Troubleshooting in chain-termination sequencing. Nucleic Acids Sequencing: A Practical Approach, pages: 79-97, Oxford University Press, IRL, 1989.       

19      Ward, E. S. Sequencing of double-stranded DNA. Nucleic Acids Sequencing: A Practical Approach, pages: 99-115, Oxford University Press, IRL, 1989.    Local PDF     ward1989e

1988

18      Maciejowski, J. M. and Ober, R. J. Balanced parametrizations and canonical forms for system identification. In Proceedings 8th IFAC Symposium on System Identification and Parameter Estimation, Beijing, 1988.     

17      Ober, R. J. The parametrization of linear systems using balanced realizations: relaxation systems. Linear Circuits, Systems and Signal Processing : Theory and Application, New York, 1988.    

16       Ward, E. S. and Ellar, D. J. Cloning and expression of two homologous genes of Bacillus thuringiensis subsp. israelensis which encode 130-Kilodalton mosquitocidal proteins. Journal of Bacteriology, 170: 727-735, 1988.      Journal URL     

15      Ward, E. S., Ellar, D. J., and Chilcott, C. N. Single amino acid changes in the Bacillus thuringiensis var. israelensis delta-endotoxin affect the toxicity and expression of the protein. Journal of Molecular Biology, 202: 527-535, 1988.      Journal URL     http://dx.doi.org/doi:10.1016/0022-2836(88)90283-5

1987

14      Ober, R. J. Topology of the set of asymptotically stable minimal systems. International Journal of Control, 46: 263-280, 1987.      Journal URL   http://dx.doi.org/10.1080/00207178708933897

13      Ober, R. J. Balanced realizations: canonical form, parametrization, model reduction. International Journal of Control, 46: 643-670, 1987.     Journal URL  http://dx.doi.org/10.1080/00207178708933920

12     Ober, R. J. A parametrization approach to infinite-dimensional balanced systems and their approximation. IMA J Math Control Info, 4: 263-280, 1987.   Journal URL   http://dx.doi.org/doi:10.1093/imamci/4.4.263

11     Ober, R. J. A note on a system theoretic approach to a conjecture by Peller-Khrushchev. Systems & Control Letters, 8: 303-306, 1987.     Journal URL   http://dx.doi.org/doi:10.1016/0167-6911(87)90095-8

10     Ober, R. J. Asymptotically stable allpass transfer functions: canonical form, parametrization and realization.  Proceedings IFAC World Congress, 1987.  

9       Earp, D. J., Ward, E. S., and Ellar, D. J. Investigation of possible homologies between crystal proteins of three mosquitocidal strains of Bacillus thuringiensis.  FEMS Letters, 42: 195-199, 1987.      Journal URL     http://dx.doi.org/10.1111/j.1574-6968.1987.tb02071.x

8       Haider, M. Z., Ward, E. S., and Ellar, D. J. Cloning and heterologous expression of an insecticidal delta-endotoxin gene from Bacillus thuringiensis var. aizawai IC1 toxic to both lepidoptera and diptera. Gene, 52: 285-290, 1987.      Journal URL     http://dx.doi.org/doi:10.1016/0378-1119(87)90055-2

7       Ward, E. S., and Ellar, D. J. Nucleotide sequence of a Bacillus thuringiensis var. israelensis gene encoding a 130 kDa delta-endotoxin. Nucleic Acids Research, 15: 7195, 1987.      Journal URL      

1986

6       Ober, R. J. Infinite dimensional balanced realizations and their approximation.  In Proceedings of the 25th IEEE Conference on Decision and Control, 155-156, 1986.    Journal URL http://dx.doi.org/10.1109/CDC.1986.267197 

5       Ward, E. S., Ridley, A. R., Ellar, D. J., and Todd, J. A. Bacillus thuringiensis var. israelensis delta-endotoxin. Cloning and expression of the toxin in sporogenic and asporogenic strains of Bacillus subtilis. Journal of Molecular Biology, 191: 13-22, 1986.      Journal URL    http://dx.doi.org/doi:10.1016/0022-2836(86)90418-3

4       Ward, E. S. and Ellar, D. J. Bacillus thuringiensis var. israelensis delta-endotoxin: Nucleotide sequence and characterization of the transcripts in Bacillus thuringiensis and Escherichia coli. Journal of Molecular Biology, 191: 1-11, 1986.    Journal URL   http://dx.doi.org/doi:10.1016/0022-2836(86)90417-1

1985

3       Ellar, D. J., Thomas, W. E., Knowles, B. H., Ward, E. S., Todd, J. A., Drobniewskie, F., Lewis, J., Sawyer, T., and Nichols, C. Biochemistry, genetics, and mode of action of Bacillus thuringiensis delta-endotoxins.  Molecular Biology of Microbial Differentiation, 230-240, 1985.   

1984

2       Ward, E. S., Ellar, D. J., and Todd, J. A. Cloning and expression in Escherichia coli of the insecticidal delta-endotoxin gene of Bacillus thuringiensis var. israelensis. FEBS Letters, 175: 377-382, 1984.      Journal URL     http://dx.doi.org/doi:10.1016/0014-5793(84)80772-3

1983

1       Ward, E. S., and Ellar, D. J. Assignment of the delta-endotoxin gene of Bacillus thuringiensis var israelensis to a specific plasmid by curing analysis. FEBS Letters, 158: 45-49, 1984.   Journal URL http://dx.doi.org/doi:10.1016/0014-5793(83)80673-5

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