My research interests revolve around fundamental immunological problems. Presently, I am involved in the project related to structure-function studies of the human neonatal Fc receptor, FcRn and its role in intracellular trafficking of IgGs and immune complexes at blood tissue barriers.
My research work heavily uses live-cell imaging approaches. Towards this end, I have been developing (as part of my doctoral and postdoctoral work) a variety of tools and technologies for imaging the intracellular trafficking pathways in live cells in 2D/3D at single molecule resolution. The following is a brief list of the past and present work.
Single molecule microscopy
Single molecule localization and tracking
Multifocal plane microscopy (MUM)
Statistical Image Processing
COMMENTARY ABOUT MY WORK
1. Xavier Michalet and Shimon Weiss, “Photon statistics to boost microscopy resolution'', Proceedings of the National Academy of Sciences, 103, 4797-4798, 2006 [full-text].
2. Rajendrani Mukhopadhyay, “Multifocal plane imaging reveals exocytosis dynamics: Meeting News - 51st Annual Meeting of the Biophysical Society'', Analytical Chemistry, 79, 3958, 2007 [full-text].
3. Hong-Wu Shen and Ai-Ming Yu, “New analytical technologies for biological discovery”, Bioanalysis, 2(2), 181-184 [full-text].