The Winkler research laboratory is broadly interested in microbial metabolism, RNA structure and function, and the biochemical underpinnings of genetic regulatory mechanisms. These seemingly disparate fields of study overlap with the investigation of posttranscriptional control in gram-positive bacteria, for which we utilize Bacillus subtilis as a model organism. Our efforts to discover and characterize these regulatory mechanisms will lead to improved strategies for the molecular engineering of ‘designer’ genetic tools, as well as provide metabolic insight into the function of the regulated genes. We use a combination of biochemistry, molecular biology, and genetic experimentation in pursuit of these goals.

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Last updated May, 2007. Copyright 2005 University of Texas Southwestern Medical Center.