Selected Publications by W. C. Winkler and the Winkler Laboratory:
Roth A., Winkler WC, Regulski EE, Lee BW, Lim J, Jona I, Barrick JE, Ritwik A, Kim JN, Welz R, Iwata-Reuyl D, and Breaker RR. 2007. A riboswitch selective for the queuosine precursor preQ(1) contains an unusually small aptamer domain. Nature Structural and Molecular Biology 14:308-317.
Irnov, Kertsburg A, Winkler WC. 2006. Genetic control by cis-acting regulatory RNAs in Bacillus subtilis: General principles and prospects for discovery. Cold Spring Harbor Symposium on Quantitative Biology 71:239-249.
Winkler WC, Dann CE 3rd. 2006. RNA allostery glimpsed. Nature Structural and Molecular Biology. 13:569-571. News and Views Commentary.
Lim J, Winkler WC, Nakamura S, Scott V, Breaker RR. 2005. Molecular-recognition characteristics of SAM-binding riboswitches. Agnew Chem Int Ed Engl. 45:964-968.
Winkler WC. 2005. Riboswitches and the role of noncoding RNAs in bacterial metabolic control. Current Opinion in Chemical Biology 9:594-602.
Winkler WC, Breaker RR. 2005. Regulation of bacterial gene expression by riboswitches. Annual Review of Microbiology 59:487-517.
Wickiser JK, Winkler WC, Breaker RR, Crothers D. 2005. The speed of RNA transcription and metabolite binding kinetics operate an FMN riboswitch. Molecular Cell 18:49-60.
Winkler WC. 2005. Metabolic monitoring by bacterial mRNAs. Archives in Microbiology 183:151-9.
Barrick JE, Corbino KA, Winkler WC, Nahvi A, Mandal M, Collins J, Lee M, Roth A, Sudarsan N, Jona I, Wickiser JK, Breaker RR. 2004. RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control. Proceedings of the National Academy of Sciences, United States of America. 101:6421-6426.
Winkler WC, Nahvi A, Roth A, Collins JA, Breaker RR. 2004. Control of bacterial gene expression by a natural metabolite-responsive ribozyme. Nature 428:281-286.
Winkler WC, Breaker RR. 2003. Genetic control by metabolite-binding riboswitches. ChemBioChem. 4:1024-1032.
Winkler WC, Nahvi A, Sudarsan N, Barrick JE, Breaker RR. 2003. An mRNA structure that controls gene expression by binding S-adenosylmethionine. Nature Structural Biology 10:701-707.
Mandal M, Boese B, Barrick JE, Winkler WC, Breaker RR. 2003. Metabolite-sensing riboswitches control fundamental biochemical pathways in bacteria. Cell 113:577-586.
Winkler WC, Cohen-Chalamish S, Breaker RR. 2002. An mRNA structure that controls gene expression by binding FMN. Proceedings of the National Academy of Sciences, United States of America. 99:15908-15913.
Winkler W, Nahvi A, Breaker RR. 2002. Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Nature 419:952-956.
Grundy FJ, Winkler WC, Henkin TM. 2002. tRNA-mediated transcription antitermination in vitro: Codon-anticodon pairing independent of the ribosome. Proceedings of the National Academy of Sciences, United States of America. 99:11121-11126.
Winkler WC, Grundy FJ, Murphy BA, Henkin TM. 2001. The GA motif: An RNA element common to bacterial antitermination systems, rRNA, and eukaryotic RNAs. RNA 7:1165-1172.