•  
    • JIANG WU

    University of Texas Southwestern Medical Center
    Departments of Physiology and Developmental Biology
    5323 Harry Hines Blvd.
    Dallas, TX 75390-9133
    Phone: 214-648-1824; FAX: 214-648-1960
    Email: jiang9.wu@utsouthwestern.edu
    Website: www4.utsouthwestern.edu/wulab

    EDUCATION

  • September 1995 to May, 2001, The University of Texas at Austin, Ph.D.,
    Major: Molecular Biology

  • September 1992 to June 1995, Fudan University, Master of Science,
    Major: Microbial Genetics

  • September 1988 to June 1992, Fudan University, Bachelor of Science,
    Major: Genetics

    RESEARCH EXPERIENCE

  • 2009-present, Assistant Professor, Virginia Murchison Linthicum Scholar in Medical Research, Department of Physiology and Developmental Biology, UT Southwestern Medical Center, Dallas, Texas.

  • 2002-2008, Postdoctoral fellow, HHMI/Department of Pathology and Developmental Biology, Stanford University, Stanford, California.
    Supervisor: Dr. Gerald Crabtree

  • 2001-2002, Postdoctoral fellow,
    Section of Molecular genetics and Microbiology.
    University of Texas at Austin, Austin, Texas.
    Supervisor: Dr. Karen Artzt

  • 1995-2001, Graduate Research Assistant,
    Institute for Cellular and Molecular Biology,
    University of Texas at Austin, Austin, Texas.
    Supervisor: Dr. Karen Artzt

  • 1992-1995, Graduate Research Assistant,
    Institute of Genetics,
    Fudan University, Shanghai, China,

    TEACHING

  • Co-director, Fundamentals of Neuroscience, 2009-2012,
  • Lecture: Neural stem cell and neurotrophins, 2012

    AWARDS

  • Basil O’Connor Starter Scholar Research Award, 2010
  • Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center, Dallas, Texas, 2009
  • Welch Foundation research grant award, 2009
  • Whitehall Foundation research award, 2009
  • UT at Austin Professional development award, 2000
  • The Lois Sager Foxhall memorial scholarship, 1999
  • The Mao Chengsi memorial award, 1994
  • Graduated with honor from Fudan University, 1992

    PUBLICATIONS

  • Wu, J.I. (2012) Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer. Acta Biochimica et Biophysica Sinica. 44, 54-69

  • Zhan, X., Shi, X., Zhang, Z., Chen, Y., Wu, J.I. (2011) Dual role of Brg chromatin remodeling factor in Shh signaling during neural development. Proc. Natl. Acad. Sci. USA, 108, 12758-12763. PMC315094

  • Zhan, X., and Wu, J. (2009) Epigenetics in embryonic and adult neurogenesis. Cell Science Review 6, 104-128

  • Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR.   (2009) An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A., 106(13):5181-6

  • Wu, J. I., Lessard, J., and Crabtree, G. R.  (2009) Understanding the words of chromatin remodeling. Cell, 136(2):200-6..

  • Stankunas, K., Hang, C.T., Tsun, Z.Y., Chen, H., Lee, N.V., Wu J.I., Shang, C., Bayle, J.H., Shou, W., Iruela-Arispe, M.L., Chang, C.P. (2008)  Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.  Dev. Cell 14, 298-311.

  • Wu, J. I., Lessard, J., Olave, I. A., Qiu, Z. Ghosh, A., Graef, I. A., and Crabtree, G. R. (2007). Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56, 94-108 (featured in Leading Edge Cell 131, 199; Research Focus in Trends in Cell Biology 18, 48-51; Featured article in Nature Neuroscience Gateway Oct. 2007).

  • Wu, J. I., Rajendra, R., Barsi, J.C., Durfee, L., Benito, E., Gao, G., Kuruvilla, M., Hrdlickova, R., Liss, A. S., Artzt, K. (2007) Targeted disruption of Mib2 causes exencephaly with a variable penetrance. Genesis 45, 722-727.

  • Wu, J. I., Centilli, M. A., Vasquez G., Young, S., Scolnick, J., Durfee L. A., Spearow, J. L., Schwantz S. D., Rennebeck G., and Artzt K. (2007). tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Genetics 177, 1151-1161

  • Lessard, J.*, Wu, J. I.*, Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A., and Crabtree, G. R. (2007). An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55, 201-215 (cover and preview Neuron 55, 171-173).
    *: Equal contribution.

  • Wu, J. I. and Crabtree, G. R. (2007) Cell signaling. Nuclear actin as choreographer of cell morphology and transcription. Science 316:1710-1711

  • Barsi, J.C.*, Rajendra, R.*, Wu, J.I.*,  and Artzt, K. (2005) Mind bomb 1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech. Dev. 122: 1106-1117. (cover)
    *: Equal contribution.

  • Wu, J.I., Reed R.B., Grabowski, P. J., and Artzt, K. (2002) The function of quaking in myelination:  alternative splicing regulation.  Proc. Natl. Acad. Sci. USA 99: 4233-4238.           

  • Reddy, T.R., Modem, S., Xu, W., Yeh, L., Yang, J.P., Wu, J., Artzt, K., and Wong-Staal, F. (2002) A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication . J. Biol. Chem.277: 5778-5784.

  • Wu, J., Zhou L., Tonissen k. , Tee R., and Artzt, K. (1999)  The quakingI-5 (QKI-5) protein has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.  J. Biol. Chem. 274: 29202-29210.

  • Kondo, T., Furuta, T., Mitsunaga, K., Ebersole, T.A., Shichiri, M., Wu, J., Artzt, K., Yamamura, K., and Abe, K. (1999) Genomic organization and expression analysis of the mouse qkI locus. Mamm. Genome 10:662-669.

  • Venables, J.P., Vernet, C., Chew, S.L., Cowmeadow, R.B., Wu, J., Cooke, H.J., Artzt, K. and Eperon, I.C. (1999) T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Hum Mol Genet; 8: 959-969.

  • Book Chapter

  • Artzt, K and Wu, J.I. (2010) STAR TREK: An introduction to STAR family proteins and review of QKI. Post-Transcriptional Regulation by STAR Proteins: Control of RNA Metabolism in Development and Disease Landes Bioscience, ISBN 978-1-4419-7004-6.