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He X, Kuo Y, Rosche YJ, Zhang X.
Structural basis for auto-inhibition of the guanine nucleotide exchange factor FARP2.
Structure . 2013, ePub ahead of print Link to Pubmed
Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J and Shaw DE.
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization.
Cell. 2012 May 11; 149(4):860-70 Link to Pubmed
Wang Y, He H, Srivastava N, Vikarunnessa S, Chen Y, Jiang J, Cowan C, Zhang X.
Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.
Sci. Signaling. 2012 Jan 17; 5, ra6 Link to Pubmed
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Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J.
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Mol. Cell. 2011 Apr 8; 42(1):9-22. (review).Link to Pubmed
Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J.
Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.
Nat Rev Urol. 2011 Mar;8(3):165-71. Epub 2011 Feb 8a.Link to Pubmed
Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J#, Zhang X#.
Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1.
Biochemistry. 2010; 49(11): 2491-501. (#corresponding authors) Link to PubMed
He H, Yang T, Terman JR, Zhang X.
Crystal Structure of the Plexin A3 Intracellular Region Reveals an Autoinhibited Conformation Through Active Site Sequestration.
Proc Natl Acad Sci U S A. 2009; 100: 2586-2591. Link to PubMed
Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, and Kuriyan J.
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Cell. 2009; 137: 1293-1307. Link to PubMed
Bose R, Zhang X.
The ErbB Kinase Domain: Structural Perspectives into Kinase Activation and Inhibition.
Exp Cell Res. 2008. 15:649-58. (Review) (Co-corresponding authors). Link to PubMed
Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J.
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature. 2007 Nov 29;450(7170):741-4. Link to PubMed
Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J.
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell. 2006 Jun 16;125(6):1137-49. Link to PubMed
Zhang X *, Schwartz JC *, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC.
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity. 2004 Mar;20(3):337-47. Erratum in: Immunity. 2004 May;20(5):651. Link to PubMed
Zhang X *, Schwartz JC *, Almo SC, Nathenson SG.
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2586-91. Epub 2003 Feb 26. Link to PubMed
Zhang X *, Schwartz JC *, Almo SC, Nathenson SG.
Expression, refolding, purification, molecular characterization, crystallization,
and preliminary X-ray analysis of the receptor binding domain of human B7-2.
Protein Expr Purif. 2002 Jun;25(1):105-13. Link to PubMed
Schwartz JC *, Zhang X *, Nathenson SG, Almo SC.
Structural mechanisms of costimulation.
Nat Immunol. 2002 May;3(5):427-34. Review. Link to PubMed
Zhang X *, Schwartz JC *, Nathenson SG, Almo SC.
Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2.
Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):898-9. Epub 2001 May 25. Link to PubMed
Schwartz JC *, Zhang X *, Fedorov AA, Nathenson SG, Almo SC.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Nature. 2001 Mar 29;410(6828):604-8. Link to PubMed
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