Xuewu Zhang Lab UT Southwestern Medical Center
Department of Pharmacology
Department of Biochemistry
Recent Publications

Pubmed search for Xuewu Zhang's publications

  Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X#, Chen ZJ# and Jiang QX#.(#corresponding authors)
Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
eLife. 2014 Jan 1; 3: e01489. Link_to_journal

Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X and Chen ZJ.
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes swithc-like conformational changes in the activation loop.
Cell Rep. 2014 Feb 13;6(3):421-30. Link to Pubmed

Wang Y*, Pascoe HG*, Brautigam CA, He H and Zhang X.
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
eLife. 2013 Oct. 1.; 2: e01279. Link_to_journal

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP.
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
J. Exp. Med. 2013, ePub ahead of print Link to Pubmed

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ.
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.
Mol. Cell. 2013, ePub ahead of print Link to Pubmed

He X, Kuo Y, Rosche YJ, Zhang X.
Structural basis for auto-inhibition of the guanine nucleotide exchange factor FARP2.
Structure. 2013 March 5; 21(3):355-364 Link to Pubmed

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J and Shaw DE.
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization.
Cell. 2012 May 11; 149(4):860-70 Link to Pubmed

Wang Y*, He H*, Srivastava N, Vikarunnessa S, Chen Y, Jiang J, Cowan C, Zhang X.
Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.
Sci. Signaling. 2012 Jan 17; 5, ra6 Link to Pubmed PDF

Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J.
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Mol. Cell. 2011 Apr 8; 42(1):9-22. (review).Link to Pubmed

Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J.
Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.
Nat Rev Urol. 2011 Mar;8(3):165-71. Epub 2011 Feb 8a.Link to Pubmed

Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J#, Zhang X#.(#corresponding authors)
Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1.
Biochemistry. 2010; 49(11): 2491-501. Link to PubMed

He H, Yang T, Terman JR, Zhang X.
Crystal Structure of the Plexin A3 Intracellular Region Reveals an Autoinhibited Conformation Through Active Site Sequestration.
Proc Natl Acad Sci U S A. 2009; 100: 2586-2591. Link to PubMed

Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, and Kuriyan J.
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Cell. 2009; 137: 1293-1307. Link to PubMed

Bose R, Zhang X.(co-corresponding authors)
The ErbB Kinase Domain: Structural Perspectives into Kinase Activation and Inhibition.
Exp Cell Res. 2008. 15:649-58. (Review). Link to PubMed

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J.
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature. 2007 Nov 29;450(7170):741-4. Link to PubMed

Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J.
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell. 2006 Jun 16;125(6):1137-49. Link to PubMed

Zhang X *, Schwartz JC *, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC.
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity. 2004 Mar;20(3):337-47. Erratum in: Immunity. 2004 May;20(5):651. Link to PubMed

Zhang X *, Schwartz JC *, Almo SC, Nathenson SG.
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2586-91. Epub 2003 Feb 26. Link to PubMed

Zhang X *, Schwartz JC *, Almo SC, Nathenson SG.
Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.
Protein Expr Purif. 2002 Jun;25(1):105-13. Link to PubMed

Schwartz JC *, Zhang X *, Nathenson SG, Almo SC.
Structural mechanisms of costimulation.
Nat Immunol. 2002 May;3(5):427-34. Review. Link to PubMed

Zhang X *, Schwartz JC *, Nathenson SG, Almo SC.
Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2.
Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):898-9. Epub 2001 May 25. Link to PubMed

Schwartz JC *, Zhang X *, Fedorov AA, Nathenson SG, Almo SC.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Nature. 2001 Mar 29;410(6828):604-8. Link to PubMed

* These authors contributed equally to this work.