The University of Texas Southwestern Medical Center at Dallas



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Overview

The actin cytoskeleton has many essential functions.  Actin polymerization drives membrane movements, and actin filaments assemble into a scaffold that support the cellsí motors and signaling machinery.  The scaffold is continually remodeled in proliferating cells, and is completely dismantled in apoptotic cells.  We are studying how phosphatidylinositol 4,5 bisphosphate (PIP2), a membrane lipid, regulates the actin scaffold in proliferating and apoptotic cells. We focus on the lipid kinases that synthesize PIP2 (phosphatidylinositol phosphate 5 kinases, PIP5Ks) and PI4P (phosphatidylinositol 4 kinases, PI4Ks), as well as the regulatory proteins that respond to PIP2 and PI4P.

Projects
Click a project photograph for a full description.

    PIP2 regulates the actin cytoskeleton and vesicle transport.
    Phosphoinositide regulation of Golgi functions.
    Gelsolin regulates the actin cytoskeleton and membrane signaling.
    Plasma gelsolin protects against burn injury.

 
 

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