The University of Texas Southwestern Medical Center at Dallas


Selected Reports

      Ukena TE, HL Yin, RD Berlin. Effect of colchicine, colcemide, and vinblastine on the agglutination by concanavalin A of transformed cells. Science 1972; 178: 867-8.

      Yin HL, TP Stossel. Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent protein. Nature 1979; 218: 583-6.

      Brady S, R Lasek, RD Allen, HL Yin, TP Stossel. Gelsolin inhibition of axonal transport indicates a requirement for microfilaments. Nature 1984; 310: 56-8.

      Kwiatkowski DJ, TP Stossel, SH Orkin, JE Mole, HR Colten, HL Yin. Plasma and cytoplasmic gelsolins contain a duplicated actin-binding domain. Nature 1986; 323: 455-8.

      Kwiatkowski DJ, PA Janmey, HL Yin. Identification of critical functional and regulatory domains in gelsolin. J. Cell Biol. 1989; 108: 1717-26.

      Yu FX, PA Johnston, TC Südhof, HL Yin. gCap39, a calcium ion- and polyphosphoinositide regulated actin capping protein. Science 1990; 250: 1413-15.

      Yu FX, HQ Sun, PA Janmey, HL Yin. Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. J. Biol. Chem. 1992; 267: 14616-21.

      Yu F-X, S-C Lin, M Morrison-Bogorad, MAL Atkinson, HL Yin. Thymosin B10 and thymosin B4 are both actin monomer sequestering proteins. J. Biol. Chem. 1993; 268: 502-9.

      Sun HQ, DC Wooten, PA Janmey, HL Yin. The actin side binding domain of gelsolin also caps actin filaments. Implications for actin filament severing. J. Biol. Chem. 1994; 269: 9473-9.

      Muallem S, K Kwiatkowska, X Xu, HL Yin. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J. Cell Biol. 1995; 128: 589-98.

      Sun HQ, K Kwiatkowska, DC Wooten, HL Yin. Effects of CapG overexpression on agonist-induced motility and second messenger generation. J. Cell Biol. 1995; 129: 147-56.

      Li X, A Zimmerman, NG Copeland, DJ Gilbert, NA Jenkins, HL Yin. The mouse thymosin B4 gene: structure, promoter identification and chromosome localization. Genomics 1996; 32: 388-94.

      Sun HQ, K Kwiatkowska, HL Yin. B-thymosin is not a simple actin monomer sequestering protein. New insights from in vivo studies. J. Biol. Chem. 1996; 271: 9223-30.

      Suhler E, W Lin, H Yin, WM Lee. Decreased plasma gelsolin levels in acute liver failure, myocardial infarction, septic shock and myonecrosis. Crit. Care Med. 1997; 25: 594-8.

      Lin KM, E Wenegieme, PJ Lu, CS Chen, HL Yin. Gelsolin binding to phosphatidylinositol 4,5 bisphosphate is modulated by calcium and pH. J. Biol. Chem. 1997; 272: 20443-50.

      Sun HQ, KM Lin, HL Yin. Gelsolin modulates phospholipase C activity in vivo through phospholipid binding. J. Cell Biol. 1997; 138: 811-20.

      Lamaze C, LM Fujimoto, HL Yin, SL Schmid. The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. J. Biol. Chem. 1997; 272: 20332-5.

      Liu YT, HL Yin. Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. J. Biol. Chem. 1998; 273: 7920-7.

      Lu PJ, AL Hsu, D-S Wang, HY Yan, HL Yin, CS Chen. Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry 1998; 37: 5738-45.

      Ratnaswamy G, E Koepf, H Bekele, H Yin, JW Kelly. Unordered wild type and D187N gelsolin (173-243) form amyloid fibrils below pH 5.5; proteolysis and environment control gelsolin amyloidogenicity. Chem. Biol. 1999; 6: 293-305.

      Dahl B, FV Schiodt, P Ott, R Gvozdenovic, HL Yin, WM Lee. Plasma gelsolin is reduced in trauma patients. Shock 1999; 12: 102-4.

      Robinson RC, M Mejillano, VP Le, LD Burtnick, HL Yin, S Choe. Domain movement in gelsolin: A calcium-activated switch. Science 1999; 286: 1939-42.

      Rozelle AL*, LM Machesky*, M Yamamoto, MHE Driessens, RH Insall, MG Roth, K Luby-Phelps, G Marriott, A Hall, HL Yin. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr. Biol. 2000; 10: 311-20. (*Equal contribution)

      Lueck A, HL Yin, DJ Kwiatkowski, PG Allen. Ca2+ regulation of gelsolin and adservin: A natural test of the helix latch hypothesis. Biochem. 2000; 39: 5274-9.

      Lin KM*, M Mejillano*, HL Yin. Ca2+ regulation of gelsolin by its carboxyl-terminal tail. J. Biol. Chem. 2000; 275:27746-52. (*Equal contribution)

      Feng L, M Mejillano, HL Yin, J Chen, GD Prestwich. Full-contact domain labeling: Identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Biochemistry 2001: 40:904-13.

      Turnage RH, F Nwariaku, J Murphy, C Schulman, K Wright, HL Yin. Burn-activated neutrophils and tumor necrosis factor-alpha alter endothelial actin cytoskeleton and enhance monolayer permeability. Surgery 2000: 128:259-65.

      Peng Y, M Amemiya, X Yang, OW Moe, HL Yin, PA Preisig, M Yanagisawa, RJ Alpern. ETB receptor activation causes exocytic insertion of NHE3 in OKP cells. Am. J. Physiology (Renal) 2001; 280:F34-42.

      Mejillano M*, M Yamamoto*, AL Rozelle*, HQ Sun, X Wang, HL Yin. Regulation of apoptosis by phosphatidylinositol 4, 5 bisphosphate inhibition of caspases, and caspase inactivation of type I phosphatidylinositol phosphate 5 kinase. J. Biol. Chems. 2001; 276:1865-72. (* Equal contribution).

      Yamamoto M, D Hilgemann, S Feng, H Bito, H Ishihara, Y Shibasaki, HL Yin. Phosphatidylionsitol 4,5-bisphosphate induces actin stress fiber formation and inhibits membrane ruffling. J. Cell Biol. 2001; 152:867-76.

      Brown FD, AL Rozelle HL Yin, T Balla, JG Donaldson. Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J. Cell Biol. 2001; 154:1007-17.

      Bierne H, E Gouin, P Roux, P Caroni, HL Yin, P Cossart. A role for cofilin in Listeria-induced phagocytosis. J. Cell Biol. 2001; 155:101-12.

      Nasuhoglu C, S Feng, J Mao, M Yamamoto, HL Yin, S Earnest, B Barylko, JP Albanesi, DW Hilgemann. Non-radio active analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal. Biochem. 2002; 301:243-54.

      Wei YJ, HQ Sun, M Yamamoto, P Wlodarski, K Kunii, M Martinez, JP Albanesi, HL Yin. Type II phosphatidylinositol 4-kinases beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane in a Rac-GTP dependent manner. J. Biol. Chem. 2002;277:46586-93.

      Seth A, T Otomo, HL Yin, MK Rosen. Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. Biochem. 2003; 42:3997-4008.

      Pellieux C, A Desgeorges, CP Haziza, C Chambac HL Yin, D Havoc, P Silacci. CapG: a gelsolin-family protein modulating protective effects of unidirectional shear stress. J. Biol. Chem. 2003; 278:29136-29144.

      Rothenbach PA, B Dahl, JJ Schwartz, GE O'Keefe GE, M Yamamoto, WM Lee, JW Horton, HL Yin, RH Turnage. Recombinant plasma geloslin inufusion attenuates burn-induced pulmonray microvascular dysfunction. J. Appl. Physiol. [Epub ahead of print]

      Wang WY, J Wang, HQ Sun, M Martinez, YX Sun, E Macia, T. Kirchhausen, JA Albanesi, MG Roth, HL Yin. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 2003; 114:299-310.

      Padron, D, YJ Wang, M Yasmamoto, H Yin, MG Roth. Phosphatidylinositol phosphate 5 kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol. 2003; 162:692-301.

      Tskvitaria-Fuller I, AL Rozelle, HL Yin, C Wulfring. Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization. J. Immunol. 2003; 171:2287-95.

Selected Recent Reviews

      Sun HQ, K Kwiatkowska, HL Yin. Actin monomer binding proteins. Curr. Opin. Cell Biol. 1995; 7: 102-10.

      Liu YT, A Rozelle, HL Yin. The gelsolin family of actin filament severers and cappers. In: Maruta H, Kohama K, eds., G Proteins, Cytoskeleton and Cancer. R.G. Landes Co, Georgetown, TX, 1998; 19-35.

      Yin HL. Gelsolin. In: Kreis T, Vale R, eds., Guidebook to the Cytoskeletal and Motor Proteins. Oxford Univ. Press, N.Y.1999.

      Lu PJ, KM Lin, HL Yin, CS Chen. Differential recognition of phosphoinositides by actin regulating proteins and its physiological implications. In: Phosphoinositides. Chemistry, Biochemistry, and Biomedical Applications, K. Bruzik, ed., ACS Symp. Series 718, 1999, pp. 38-54.

      Sun HQ, KM Lin, M Yamamoto, HL Yin. The phagocyte actin cytoskeleton. In: Advances in Cell and Molecular Biology of Membranes and Organelles, Vol. 5, "Phagocytosis and Pathogens", S Gordon, ed., JAI Press, Inc., Greenwich, 1999, pp. 319-340.

      Yin HL, JT Stull. Proteins that regulate dynamic actin remodeling in response to membrane signaling. J. Biol. Chem. 1999; 274: 33179-82.

      Sun HQ, M Yamamoto, M Mejillano, HL Yin. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. 1999; 274: 32529-30.

      Turnage RH, F Nwariaku, J Murphy, C Schulman, K Wright HL Yin. Mechanism of pulmonary microvascular dysfunction during severe burn injury. World J. Surg. 2002; 26:848-853.

      Yamamoto M, K Kunii, HL Yin. Experimental Medicine 2003; 26:848-853.

      Yin HL, PA Janmey. Phosphoinositide regulation of the actin cytoskeleton. Ann. Rev. Physiol. 2003; 65:761-89.

      Janmey PA, R Buckey, HL Yin. Pyospyoinositides and actin cytoskeletal reaarrangement. Handbook of Cell Signaling 2003; in press (Acad. Press)


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